ID A0A1S3ZH56_TOBAC Unreviewed; 360 AA.
AC A0A1S3ZH56;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Trans-resveratrol di-O-methyltransferase-like {ECO:0000313|RefSeq:XP_016463651.1};
GN Name=LOC107786648 {ECO:0000313|RefSeq:XP_016463651.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016463651.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016463651.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Cation-independent O-methyltransferase family. COMT
CC subfamily. {ECO:0000256|ARBA:ARBA00034481}.
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DR RefSeq; XP_016463651.1; XM_016608165.1.
DR AlphaFoldDB; A0A1S3ZH56; -.
DR SMR; A0A1S3ZH56; -.
DR STRING; 4097.A0A1S3ZH56; -.
DR PaxDb; 4097-A0A1S3ZH56; -.
DR GeneID; 107786648; -.
DR KEGG; nta:107786648; -.
DR OMA; WANGEEL; -.
DR OrthoDB; 5230501at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0008171; F:O-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IBA:GO_Central.
DR GO; GO:0019438; P:aromatic compound biosynthetic process; IBA:GO_Central.
DR GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IBA:GO_Central.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR012967; Plant_MeTrfase_dimerisation.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11746; O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11746:SF290; TRANS-RESVERATROL DI-O-METHYLTRANSFERASE-LIKE; 1.
DR Pfam; PF08100; Dimerisation; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 32..80
FT /note="Plant methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF08100"
FT DOMAIN 133..342
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 264
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 360 AA; 40038 MW; 8BE204C0404CE103 CRC64;
MALSNNIGDE TREILAAQAH IANHVFNYLN SMSLKCAIQL EIPDIIHNHG KPMTLSNLVN
ALPINKAKGQ DCIYRLMRIL IHSGFFIQTK INETEEEEGY LLTPNSRLLL KNEPLSLVPF
VLAQLDPILM DPFQSLSKWL QNDDSTPFAT AHGKPLFEYA GEEPRLNYLF NEAMASDARL
MISVVIKTGS GIFDGLKSLV DVGGGIGTVA KAISNAFPEV KCTVFDLPHV VEGLEGSKNL
SYVGGDMFKS VPSADAILLK WILHDWSDED CVKILKKCKE AIPSKENRGK VIIIDIVVDS
QKGDNKSFET QLFSDILMMV HVSGKERNRE EWAKLFCDAG FSDYKINPIL GLRSVIEVYP
//
