ID A0A1S3ZHN8_TOBAC Unreviewed; 1248 AA.
AC A0A1S3ZHN8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Disease resistance protein RGA1 isoform X3 {ECO:0000313|RefSeq:XP_016463889.1};
GN Name=LOC107786887 {ECO:0000313|RefSeq:XP_016463889.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016463889.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016463889.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR RefSeq; XP_016463889.1; XM_016608403.1.
DR AlphaFoldDB; A0A1S3ZHN8; -.
DR GeneID; 107786887; -.
DR OMA; ISICHLE; -.
DR OrthoDB; 1025058at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039203; RGA2/3-like.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR36766:SF53; DISEASE RESISTANCE PROTEIN RGA2-LIKE; 1.
DR PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051}.
FT DOMAIN 10..92
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 168..409
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1248 AA; 143036 MW; 2FEC50EF3D7A44EE CRC64;
MADPVIGATV QVFLEKLLSL TIEEVKSLRN CKNDLKMLKK TVTMIQAFIH DAEKRQVEDQ
TVEEWLKRLE RVAEDAENVF DEFRYESLKA EVMKIRNKPM KKVCNFVSNT VLQCKMSRKI
NNINEELSAI NKLAKDLGLQ PPTGPSRQIL PIRETDSVVV ASDVVGRDKD VAEIKEKMLN
MREDVVLCTI PIVGMGGSGK TTVAKIIFND EQIKQQFEKR VWLCLPEMLE TKSFLELMLE
SLTERTLEVR SRDIIVKKLQ DELRGKKYLL VLDDLWRVDP TMWHEFGDTL RGINTSRGNC
ILVTTRRDEV ASSVGATDPY MLEILADNHC WSIFKQRAFV DGKVTEHLLG NRIVEMCKGL
PLAASVLGGL LRNKEKHEWQ TILDGNPLVA GEDDTGENRI KKILKLSYDY LPFPHLKKCF
AYFAMFPKKI EFEKDQLIQL WMAEGFLRPC QKTTVMEDAG NKFFELLLQN SLLQDVKLDE
HNNITHCKMH DLVHDLAKDI LKSKLFDAKT DGGDNLSQVR YFGWNSPRDQ IEKINEPGRL
CTLFWKSSDM SEDMLLRFQF LRVLNLSKSG IKELSASIGK LIYLRYLDLS DTKIKALPNS
ICKLYNLQTL RVNDCYGLKG FPYEMEHMIS LRHIYYNSNR SQILNIGKLT CLQTLQHFNV
GVEKGRRIEE LGHLKNLRGK LTIKGLHLVR NREEAERAYL QEKPNIYKLA YLWSHRGCEI
SDEYVLDGLR PHPNLKSFEV RSYLGSRFPS LFNEEFLPNL VKLKLIGCRK CIEIPSLGQL
KLLRHLELAE FDQLECIGPT FYGVELNNNG SSSNNANIQV FPSLKELVLE DMPSLTEWKG
VELMPTRVGV RMFPALEKLS ISNFQRLKST PNQFEVLREL SIEGVHSEMP LFSLCSNLTS
LVKLTVRNVK ELTCLPDEML HNNSFSLQHL SVLNCYVFRE LPQSLYNLHS LKSLEIEGCT
NFSSVPVPSG ENHLTSLRNL QFEGCDRLTS LPSGMLEHCR SLEFLRVNYC GNLVSLPLHL
WEMPLLSYLN ILQCSKLNSV PAGDLHHLTG LRALFIGPLS ELVDFEAFQL MFNGIQQLSS
LRTLTVYGRV KWDSLPYQLM QLSALTEMVI SNFGIQSLPR SLDNLTSLEM LTLRSCERLQ
HVDFSGVMPK LRKLKISNCP LLEALSGRLV NLVSLEELYL SNCKKLQHLP SGDDMRRLTK
LWRLRIEGCP QLEESCTNRS GPNSQWSNIS HIPKIIFSRK RASQNLLD
//
