ID A0A1S3ZJE5_TOBAC Unreviewed; 734 AA.
AC A0A1S3ZJE5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Probable cyclic nucleotide-gated ion channel 14 {ECO:0000313|RefSeq:XP_016464534.1};
GN Name=LOC107787468 {ECO:0000313|RefSeq:XP_016464534.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016464534.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016464534.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel (TC
CC 1.A.1.5) family. {ECO:0000256|ARBA:ARBA00010486}.
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DR RefSeq; XP_016464534.1; XM_016609048.1.
DR AlphaFoldDB; A0A1S3ZJE5; -.
DR STRING; 4097.A0A1S3ZJE5; -.
DR PaxDb; 4097-A0A1S3ZJE5; -.
DR GeneID; 107787468; -.
DR KEGG; nta:107787468; -.
DR OMA; RTAYESP; -.
DR OrthoDB; 3076617at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45651:SF9; CYCLIC NUCLEOTIDE-GATED ION CHANNEL 14-RELATED; 1.
DR PANTHER; PTHR45651; CYCLIC NUCLEOTIDE-GATED ION CHANNEL 15-RELATED-RELATED; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 90..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 485..568
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 651..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..679
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..726
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 734 AA; 84595 MW; 8766D32704E92D71 CRC64;
MTEFKKEKTV RFYNDGKQNF ETSWEKNENH NLEKQLPLYK SCEGRNVVDK VGASKVPKFG
NLKVFPENYV QEKKKILDPG SEIVIQWNRV FLCSCLLALF MDPLFFYMPS VVKRGKSSCM
SIDLNLGIIV TCFRTVADIF YMLHVVIKFR TAYVSRSSRV FGRGELVMDK KMIARRYLKS
DFFIDAIAAL PLPQIVIWFI IPSIRSSHSD HTNNALVLIV LLQYLPRLYL IFPLSAQIIK
AAGVVTKTAW AGAAYNLLLY MLASHVLGAS WYLLSIERYA TCWKIACREE LSPIQCSSHF
LDCGTINHAD RVTWVNSTQV FGNCNPSNST IFDFGIFANA VTNNVVSTDF LEKYLYCLWW
GLQNLSSYGQ NLSTSTFIWE TSFAILIAIL GLVLFAHLIG NMQTYLQSIT MRLEEWRLKR
RDTEEWMRHR QLPQDLQERV RRFVQYKWLA TRGVDEESIL HALPSDLRRD IQRHLCLDLV
RRVPFFSQMD DQLLDAICER LVSSLCTQGT YIVREGDPVT EMLFVIRGTL ESSTTNGGRT
GFFNSITLRA GDFCGEELLA WALLPRSTLN LPSSTRTVRA LSEVEAFALR AEDLKFVANQ
FRRLHSKKLQ HTFRYYSHHW RTWAACFVQA AWRRFKKRKL AKDLSRSESL SYATEDEQSA
NESECEHEHE HEDDQQKKTK PANSSNVKQN LGVTILASRF AANTRRGAQK MKDMDLPKLQ
KPEEPDFSAE PDDD
//
