ID   A0A1S3ZKV0_TOBAC        Unreviewed;       824 AA.
AC   A0A1S3ZKV0;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Oxysterol-binding protein-related protein 1C-like isoform X2 {ECO:0000313|RefSeq:XP_016464934.1};
GN   Name=LOC107787842 {ECO:0000313|RefSeq:XP_016464934.1};
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016464934.1};
RN   [1] {ECO:0000313|Proteomes:UP000084051}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX   PubMed=24807620; DOI=10.1038/ncomms4833;
RA   Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA   Goepfert S., Peitsch M.C., Ivanov N.V.;
RT   "The tobacco genome sequence and its comparison with those of tomato and
RT   potato.";
RL   Nat. Commun. 5:3833-3833(2014).
RN   [2] {ECO:0000313|RefSeq:XP_016464934.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: May be involved in the transport of sterols.
CC       {ECO:0000256|ARBA:ARBA00003361}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_016464934.1; XM_016609448.1.
DR   AlphaFoldDB; A0A1S3ZKV0; -.
DR   GeneID; 107787842; -.
DR   OrthoDB; 960at2759; -.
DR   Proteomes; UP000084051; Unplaced.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd13294; PH_ORP_plant; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF96; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 1A-RELATED; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF15413; PH_11; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          113..246
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          11..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          49..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          334..375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        338..352
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   824 AA;  94083 MW;  F5E6CC5088D9EF3F CRC64;
     MHPFCCVNNN YRESSPLPMP PPPPPVAEST SRSADLLNRS SSVNNYNYNH NNNWSANNSN
     HHHRHRSLTE SSSSPTAAIF TSLSRPPSMR EAIQLTCAAA SAGDQLKIND IVGNGISGIL
     HKWVNYGKGW RPRWFVLQDG VLSYYKIHGP DRIVVNSETE KGSKVIGEES LRRISRTRPN
     KITNASTSQA RRKPVGEVHL KVSSIRESRS DDRRFSIFTG TKRLHLRAET REDRIAWVEA
     LQAVKDMFPR LSNSELMAPV DNVAVSTDKL RQRLLKEGVS EAAIQDSEQI MRNEFASLQN
     QLMVLKQKHW LLMDTLRQLE TEKVDLENTV VDESQRQWKD VGPSTRLRQD KYSASASESE
     DDNERVDAAE EDTDDEENAF FDTRDFLSSS SFKSSGSDFR TSSFSSDEDD LYAYASDESV
     DPVIRSVGTK FPHVKRRKKL PNPIEKEKGV SLWSMIKDNI GKDLTKVCLP VYFNEPLSSL
     QKSFEDLEYS YLLDRASEWG RRGDSLMRIL NVAAFAVSAY ASTEGRICKP FNPLLGETYE
     ADYPDKGLRF FSEKVSHHPM IIACHCEGTG WKFWGDSILK SKFWGRSIQL DPVGILTLEF
     DDGEIFQWSK VTTSIYNLIL GKLYCDHYGT MRIQGSHNYS CKLKFKEQSI IDRNPHQVQG
     IVQDRSGKTV ATLFGKWDES MHYVNGDCSI GKGFDSVSEA HLLWKRSKPP KNPTRYNLTR
     FAITMNELIP GLKDQLPPTD SRLRPDQRCL ENGEYDRANS EKLRLEERQR QARKMQERGW
     KPRWFAKDKG GDSYSYIGGY WEAREKGKWE ACPDIFGHIP SDQM
//