ID A0A1S3ZPS1_TOBAC Unreviewed; 637 AA.
AC A0A1S3ZPS1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN Name=LOC107789127 {ECO:0000313|RefSeq:XP_016466381.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016466381.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016466381.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
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DR RefSeq; XP_016466381.1; XM_016610895.1.
DR AlphaFoldDB; A0A1S3ZPS1; -.
DR SMR; A0A1S3ZPS1; -.
DR STRING; 4097.A0A1S3ZPS1; -.
DR PaxDb; 4097-A0A1S3ZPS1; -.
DR GeneID; 107789127; -.
DR KEGG; nta:107789127; -.
DR OMA; NGAWGES; -.
DR OrthoDB; 608at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11764:SF19; TERPENE CYCLASE_MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU362003};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 98..357
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 487..630
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 637 AA; 73190 MW; 4920767095212238 CRC64;
MWKLKIAEGE GPWLKTTNNY IGRQYWEFDS EAGTPEERAL VEKVRQDFKN NRFLQKQSAD
LLMRMQLRKE NPCVPIPAAV KLEESENITE EAVKTTLKRS ISYYSTIQAN DGHWPAESAG
PLFFLPPLVM ALYVTGDMNA VLSPAHQIEI KRYTYNHQNE DGGWGFHIEG HSTMFGTVFN
YIALRLLGED GEDKALAKGR KWILDHGAAV ATPSWGKFWL AVLGVYEWDG CNPMPPEFWL
LPTLFPIHPG KMLCYGRLVY MPMSYLYGKR FVGTITSLVQ SIRDEIHNQP YYEIDWNKAR
NTCAKEDLYY PHPLIQDTLW GFLHHFAEPV LKRWPFTKLR EKALNLAMEH IRYEDENSRY
ICIGCVEKVL CLIACWVEDP NSEAYKRHIA RLPDYYWISE DGLKFQSFGC QTWDAVFSIQ
AILSSDLAAE FGPTLKKAND FLKASQVHHK KLNLTFFLFF FITVMVKLRV RAVETASCDK
IYKYRTGCWG ICYTYGTWFA VDGLIACGRT YPTCHALQKA CKFLLSKQLP DGGWGESYLS
NSNKVYTNIK GDQSNLVQTS WALLSLINAG QAEIDPTPIH RGIGLLINSQ MEDGDYPQQG
ITGAFMKNCT LNYASYRNIF PIWALGEYRK RFLMKLK
//
