ID A0A1S4A2S3_TOBAC Unreviewed; 429 AA.
AC A0A1S4A2S3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=ethanolamine-phosphate cytidylyltransferase {ECO:0000256|ARBA:ARBA00024221};
DE EC=2.7.7.14 {ECO:0000256|ARBA:ARBA00024221};
DE AltName: Full=CTP:phosphoethanolamine cytidylyltransferase {ECO:0000256|ARBA:ARBA00031473};
GN Name=LOC107793098 {ECO:0000313|RefSeq:XP_016470870.1,
GN ECO:0000313|RefSeq:XP_016470871.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016470871.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016470870.1, ECO:0000313|RefSeq:XP_016470871.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.
CC {ECO:0000256|ARBA:ARBA00024191}.
CC -!- SIMILARITY: Belongs to the cytidylyltransferase family.
CC {ECO:0000256|ARBA:ARBA00010101}.
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DR RefSeq; XP_016470870.1; XM_016615384.1.
DR RefSeq; XP_016470871.1; XM_016615385.1.
DR STRING; 4097.A0A1S4A2S3; -.
DR PaxDb; 4097-A0A1S4A2S3; -.
DR GeneID; 107793098; -.
DR KEGG; nta:107793098; -.
DR OMA; KKYYAQR; -.
DR OrthoDB; 5474784at2759; -.
DR UniPathway; UPA00558; UER00742.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004306; F:ethanolamine-phosphate cytidylyltransferase activity; IBA:GO_Central.
DR GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IBA:GO_Central.
DR CDD; cd02174; CCT; 1.
DR CDD; cd02173; ECT; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR041723; CCT.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR044608; Ect1/PCYT2.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 2.
DR PANTHER; PTHR45780; ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR45780:SF5; ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF01467; CTP_transf_like; 2.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 2.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotidyltransferase {ECO:0000313|RefSeq:XP_016470870.1,
KW ECO:0000313|RefSeq:XP_016470871.1};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Transferase {ECO:0000313|RefSeq:XP_016470870.1,
KW ECO:0000313|RefSeq:XP_016470871.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 68..197
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT DOMAIN 266..361
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
SQ SEQUENCE 429 AA; 47857 MW; BFF54159548F8368 CRC64;
MDFENNNWVW EGMYYYPRLF GGIMLTAALL GLSTGYFVGI SVPTLLYPFA DRSIFHKKKH
GKKRIHVYMD GCFDLMHYGH ANALRQAKAL GDELVVGVVS DEEIIATKGP PVLCMEERLA
LVSGLKWVDE VISSAPYEIT EEFMNRLFNE YNIDYIIHGD DPCLLPDGTD AYALAKKAGR
YKQIKRTEGV SSTDIVGRIL SSAKSRNTPQ DCSNSSPTGE ADSIKNKCGE EKQAKGGHIS
HFLPTSRRIV QFSNGKGPGP NSRVVYIDGA FDLFHAGHVE ILRRARQLGD FLLVGIYPDQ
TVSELRGHQY PLMNLYERSL SVLACRYVDE VIIGAPWEVT QDMITTFNIS VVVHGTVSES
NSSMEGGQDP YAVPKSMGIF QVIESPKDIT TTSVAQRIIA NHEIYVKRNT KKAASEKKYY
AQRKYVSGD
//
