ID A0A1S4ADZ6_TOBAC Unreviewed; 819 AA.
AC A0A1S4ADZ6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN Name=LOC107796568 {ECO:0000313|RefSeq:XP_016474849.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016474849.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016474849.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR RefSeq; XP_016474849.1; XM_016619363.1.
DR AlphaFoldDB; A0A1S4ADZ6; -.
DR SMR; A0A1S4ADZ6; -.
DR STRING; 4097.A0A1S4ADZ6; -.
DR PaxDb; 4097-A0A1S4ADZ6; -.
DR GeneID; 107796568; -.
DR KEGG; nta:107796568; -.
DR OMA; IFYKWIS; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF72; V-TYPE PROTON ATPASE SUBUNIT A1; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 422..445
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 466..484
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 547..567
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 579..600
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 631..654
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 756..777
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 97..126
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 819 AA; 93697 MW; 44DA7D537CD62F68 CRC64;
MEYIDNLPPM DLMRSENMTF VQLIIPVESA HPAITYLGQL GLLQFRDLND DKSPFQRTFV
NQVKRCAEMS RKLRFFKDQI QKAGLLPSPR PASQPDIELE ELEIQLAEHE HELIEMNANS
EKLRQSYNEL LEFKLVLQKA SDFLVSSRSH TTAQETELDE NVYSNHNYSD TASLLEQEMQ
PELSNQSGVR FISGIICKSK VLQFERMLFR ATRGNMLFHQ AVADEEILDP TSNEMVEKIV
FVVFFSGEQA RTKILKICEA FGANCYPVPE DMTKRRQITR EVLSHLSELE TTLDVGLRHR
DKALTSIGFH LTKWMNMVRR EKAVYDTLNM LNFDVTKKCL VGEGWCPIFA KTKIQEALQR
ATIDSNSQVG IVFHVMGAVD SPPTYFRTNR FTNAYQEIVD AYGVAKYQEA NPAVYTIVTF
PFLFAVMFGD WGHGICLLLG ALVLISKESK LSSQKLGSFM EMLFGGRYVL LLMSIFSIYC
GLIYNEFFSV PFHIFGGSAY KCRDASCSDA YTVGLIKYSD PYPFGVDPSW RGSRSELPFL
NSLKMKMSIL LGVAQMNLGI ILSYFNARFF NNTLDIKYQF VPQVIFLNSL FGYLSLLIVV
KWCTGSQADL YHVMIYMFLS PFEALGENQL FWGQSVLQVV LLLLALVAVP WMLFPKPFIL
KRLYTERFQG GTYGLLGTSE VDTYEEPDSA RQHHHEEFNF SEVFVHQMIH SIEFVLGAVS
NTASYLRLWA LSLAHSELST VFYEKVLLLA WGYDSLIIRL IGLAVFAFAT TFILLMMETL
SAFLHALRLH WVEFQNKFYH GDGYKFKPFS FAALADDED
//
