ID A0A1S4AFI3_TOBAC Unreviewed; 240 AA.
AC A0A1S4AFI3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=caffeoyl-CoA O-methyltransferase {ECO:0000256|ARBA:ARBA00012165};
DE EC=2.1.1.104 {ECO:0000256|ARBA:ARBA00012165};
GN Name=LOC107797097 {ECO:0000313|RefSeq:XP_016475445.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016475445.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016475445.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(E)-caffeoyl-CoA + S-adenosyl-L-methionine = (E)-feruloyl-CoA
CC + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:16925,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:87136, ChEBI:CHEBI:87305; EC=2.1.1.104;
CC Evidence={ECO:0000256|ARBA:ARBA00000581};
CC -!- PATHWAY: Aromatic compound metabolism; phenylpropanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004928}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Cation-dependent O-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00023453}.
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DR RefSeq; XP_016475445.1; XM_016619959.1.
DR AlphaFoldDB; A0A1S4AFI3; -.
DR SMR; A0A1S4AFI3; -.
DR STRING; 4097.A0A1S4AFI3; -.
DR PaxDb; 4097-A0A1S4AFI3; -.
DR GeneID; 107797097; -.
DR KEGG; nta:107797097; -.
DR OMA; PYDMIFI; -.
DR OrthoDB; 379471at2759; -.
DR UniPathway; UPA00711; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0042409; F:caffeoyl-CoA O-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IBA:GO_Central.
DR GO; GO:0009809; P:lignin biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002935; SAM_O-MeTrfase.
DR PANTHER; PTHR10509:SF97; CAFFEOYL-COA O-METHYLTRANSFERASE 5; 1.
DR PANTHER; PTHR10509; O-METHYLTRANSFERASE-RELATED; 1.
DR Pfam; PF01596; Methyltransf_3; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51682; SAM_OMT_I; 1.
PE 3: Inferred from homology;
KW Lignin biosynthesis {ECO:0000256|ARBA:ARBA00022733};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 240 AA; 27156 MW; 359F3A375CDFB067 CRC64;
MAENGIKHQE VGHKSLLQSD ALYQYILETS VYPREPESMK ELREVTAKHP WNLMTTSADE
GQFLNMLLKL INAKNTMEIG VYTGYSLLAT ALAIPDDGKI LAMDINRENY EIGLPIIEKA
GVAHKIEFRE GPALPVLDQL VEDKKNHGTY DFIFVDADKD NYINYHKRII DLVKVGGLIG
YDNTLWNGSV VAPPDAPMRK YVRYYRDFVL ELNKALAVDP RIEICMLPVG DGITLCRRIS
//
