ID A0A1S4ARN0_TOBAC Unreviewed; 977 AA.
AC A0A1S4ARN0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=LOC107800491 {ECO:0000313|RefSeq:XP_016479153.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016479153.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016479153.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC DDX11/CHL1 sub-subfamily. {ECO:0000256|ARBA:ARBA00008435}.
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DR RefSeq; XP_016479153.1; XM_016623667.1.
DR STRING; 4097.A0A1S4ARN0; -.
DR PaxDb; 4097-A0A1S4ARN0; -.
DR GeneID; 107800491; -.
DR KEGG; nta:107800491; -.
DR OMA; HNIADHC; -.
DR OrthoDB; 124793at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IBA:GO_Central.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProt.
DR GO; GO:0032508; P:DNA duplex unwinding; IBA:GO_Central.
DR GO; GO:0034085; P:establishment of sister chromatid cohesion; IBA:GO_Central.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472:SF41; ATP-DEPENDENT DNA HELICASE DDX11-RELATED; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_016479153.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051}.
FT DOMAIN 4..440
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 175..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 977 AA; 110693 MW; 2457D56E2CAB1911 CRC64;
MEERREFPAF PYEPYSIQLD FMNSLYHSLT KGGVAMLESP TGTGKTLSII CSALQWLLDR
KQQQKTQWES PSNLSGKQED YLGAEDEPDW MRNFVINKDT KSPEKKTKKK KQLGFDKRFD
RKGKREVVRD LITNGGGKEE DTEIEKVNNL MAKHEVEGMD EEEFLVEEEF LVEEYESDDE
NGGQSKRKGG GVLVNSSSEE EKDEDSMEDE EEEARPKIYF CSRTHSQLSQ FVKELRKTKF
AAEVKVVCLG SRKNFCINQE VLKLGSSTQI NERCLELQKS RKIENSKISK TKDIGAGGRA
RRSKSSSGCP MHRNHKRGKE FQSEVSQQGP MDIEDLVQIG RDLKTCPYYG SRSLVHTADL
VVLPYQSLLS KSSRESLGLS LKDSVVIIDE AHNLADSLVS MYDSKITFVQ LELVHSHLES
YFVRFRNLLG PGNRRYIQII MVLTRAFLQA LGNENCQSNF DPVCNAEGSK SGFDSSMAIN
EFLFAHNIDN INLFKLLRYI EESNIIHKVC GYGHKLALSE EVSALKMDDQ SSHDESALSG
FRALVNVLLS LTNRDGDGRI IISKTRPKCS RQQGGYLKYV MLTGERIFSE ILNQAHAVIL
AGGTLQPIEE TKERLFPWSP PDQLHFFSCG HIIPSENILP IVVSQGPSRH SFDFSYSARS
SSVTIQELGL LVSNLVNLVP EGMVIFFSSF DYEGQVYDTW KESGIIGRIM KRKRIFREPR
KSTDVETVLK EYKETIDALS HNSSKQDTVS RNGAILLAIV GGKVSEGINF SDGMGRCIVM
VGLPYPSPAD IELMERIKHI EGFDTASGKN TKFQAPRSWY SGDAQAGLDI LKSCKHRGKQ
YYENLCMKXI LILKYNLMSD IIAIRHINDY AAILLVDTRY TFDSSERSSS HSTNKLPQWI
KSRLVSATKN YGELHKLLHQ FFKFHKGKED KDFGPKKPAL HLKALDTIDT NSNSYSIKGK
FWPCFNYYLG SQWSKTA
//
