ID A0A1S4B384_TOBAC Unreviewed; 447 AA.
AC A0A1S4B384;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=4-coumarate--CoA ligase 2-like {ECO:0000313|RefSeq:XP_016483253.1};
GN Name=LOC107803965 {ECO:0000313|RefSeq:XP_016483253.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016483253.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016483253.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene
CC biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004930}.
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DR RefSeq; XP_016483253.1; XM_016627767.1.
DR STRING; 4097.A0A1S4B384; -.
DR PaxDb; 4097-A0A1S4B384; -.
DR GeneID; 107803965; -.
DR KEGG; nta:107803965; -.
DR OMA; ACFQLSG; -.
DR OrthoDB; 1404660at2759; -.
DR UniPathway; UPA00372; UER00547.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0016207; F:4-coumarate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0016405; F:CoA-ligase activity; IBA:GO_Central.
DR GO; GO:0009698; P:phenylpropanoid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd05904; 4CL; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24096:SF149; 4-COUMARATE--COA LIGASE 1-RELATED; 1.
DR PANTHER; PTHR24096; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|RefSeq:XP_016483253.1};
KW Phenylpropanoid metabolism {ECO:0000256|ARBA:ARBA00023051};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051}.
FT DOMAIN 3..305
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 356..431
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_016483253.1"
SQ SEQUENCE 447 AA; 49134 MW; 8F085359E4AA580E CRC64;
NXPFYTPSEI TKQAKASNVK LIITQSCYVD KVKSFAKENE VKIMCTDNSP PEYGRLSFTE
LITQSEEDNH NHDHNTLISD IKISPDDVVA LPYSSGTTGL PKGVMLTHKG LVTSIAQQVD
GENPNLYFNS EDVIMCVLPL FHIYSLNSVL LCGLRVGATI LIMQKFEIKG LMELVEKYKV
TIAPFVPPII LAIAKSPLVD KYDLSSIRMI MSGAAPMGKE LEDTVRAKLP NAILGQGYGM
TEAGPVLSMC LAFAKQQFEV KSGSCGTVVR NAEMKIVDTN SGASLPRNHA GEICIRGDQI
MKGYLNNPKA TEETIDKEGW LHTGDIGYID EDDQVFIVDR LKELIKYKGY QVAPAELEAL
LISNPNLTDA AVVPMKDEVA GEVPVAFVVR ANGSNISEEE IKKYISEQVI FYKRINRVFF
TEAIPKAPSG KILRKDLRAK LAASLAS
//
