ID A0A1S4B617_TOBAC Unreviewed; 1155 AA.
AC A0A1S4B617;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Formin-like protein {ECO:0000256|RuleBase:RU361260};
GN Name=LOC107804882 {ECO:0000313|RefSeq:XP_016484309.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016484309.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016484309.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin-like family. Class-II subfamily.
CC {ECO:0000256|ARBA:ARBA00006468}.
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DR RefSeq; XP_016484309.1; XM_016628823.1.
DR AlphaFoldDB; A0A1S4B617; -.
DR SMR; A0A1S4B617; -.
DR STRING; 4097.A0A1S4B617; -.
DR PaxDb; 4097-A0A1S4B617; -.
DR GeneID; 107804882; -.
DR KEGG; nta:107804882; -.
DR OMA; HYITRRT; -.
DR OrthoDB; 396031at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.1110; -; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR014020; Tensin_C2-dom.
DR PANTHER; PTHR45733; FORMIN-J; 1.
DR PANTHER; PTHR45733:SF10; FORMIN-LIKE PROTEIN 15A-RELATED; 1.
DR Pfam; PF02181; FH2; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR SMART; SM00498; FH2; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS51444; FH2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051}.
FT DOMAIN 200..340
FT /note="C2 tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51182"
FT DOMAIN 744..1143
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 378..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1132..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1024..1051
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 383..401
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..729
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1155 AA; 128710 MW; 8B1EBB2F1486D395 CRC64;
MALFRRFFYR KPPDRLLEIS ERVYVFDCCF STDALDEYEY KTYMGGIVAQ LQDHYPDASF
MVFNFKEGDQ RSQISDILTQ YDMTVMDYPR RYEGCPVLPL EMIKHFLRSS ESWLSLEGQQ
NVLLMHCERG GWPVLAFMLA GLLLYREQYT GEQKTLDMVY RQAPRELLYV LSPLNPQPSQ
LRYLHYITRR TIGLDWLPSD IPFALDCIIL RVLPLFDGGK GCRLVVRVYG QDPASTTSNR
SSKLLFSTSK TKQHGRLYRQ EECALVKIDI HCRVQGDVVL ECIHLEDDLV REEMIFRVMF
HTAFIRSNVL MLTRDEVDVP WDAKDQFSRE FKAEVLFSDA DAVPSIITVE APDEDDNETE
GDSPEEFFEV EEIFSNVIDG PDGRGESDAH SVQDSMQDDD STEIWKEELE HHAFQDSAFI
DVNRKQERNA DSTQQASKTN GLAHNDDLIN SKAVISDVSS DKDSKAGTHG ASVISEEVEN
KQDIEGTFRQ ERQGSQQKLT TDISKGKNEK APSSLKKQLV SNSKLAVDGI GPKDKSKQKE
SQGTLLRLAK PNAVSRWIPS NKGSYTNSMH VAYPPSRYKS APPVLAVTKD SQSGLKSKSS
SPRASSEAKI PAGAGRVPKK HSSCPASLDM STVKEAPVAM TSSSESVESQ AYDLQESPQS
PLPSSLPSFR YPSTSSLELP PIQEASNNLP DSATLPVSSL ETDITTDSLS HLSPRPPGGG
PPPPPLFGAK GPGAAGRGIP AGRAPILSRT RSNLKPLHWS KVTRALQGSL WEELQRHGEP
QIAPEFDVSE IEVLFSATPK SSSSGKSGGR KKSAESKPDK VHLVDLRRAN NTEIMLTKVK
MPLPDMMAAA LAMDESILDA DQVENLIKFC PTKDEMDLLK GYTGDKELLG KCEQFFLELM
KVPRVESKLR VFLFKIQFKS QVTDFKKSLT TVNSACEEVR NSSKLKEIMK KILFLGNTLN
QGTARGSAIG FKLDSLLKLT DTRATNNKMT LMHYLCKVLA SKSPALLDFH EDLVSVEAAS
KIQLKSLAEE MQAIIKGLEK VKKELEASEN DGPVSEIFCK TLKEFIGASE AEVGSLRELY
SVAGRNADAL ALYFNEDPAK CPFEQVTATL LNFVRLFRKA HEENLKQAEL DKKKVQKEAE
TENAEGSNLT KKGEK
//
