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Database: UniProt
Entry: A0A1S4BCY3_TOBAC
LinkDB: A0A1S4BCY3_TOBAC
Original site: A0A1S4BCY3_TOBAC 
ID   A0A1S4BCY3_TOBAC        Unreviewed;       291 AA.
AC   A0A1S4BCY3;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=General transcription and DNA repair factor IIH subunit TFB4 {ECO:0000256|RuleBase:RU368090};
DE   AltName: Full=RNA polymerase II transcription factor B subunit 4 {ECO:0000256|RuleBase:RU368090};
GN   Name=LOC107807025 {ECO:0000313|RefSeq:XP_016486790.1};
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016486790.1};
RN   [1] {ECO:0000313|Proteomes:UP000084051}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX   PubMed=24807620; DOI=10.1038/ncomms4833;
RA   Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA   Goepfert S., Peitsch M.C., Ivanov N.V.;
RT   "The tobacco genome sequence and its comparison with those of tomato and
RT   potato.";
RL   Nat. Commun. 5:3833-3833(2014).
RN   [2] {ECO:0000313|RefSeq:XP_016486790.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the general transcription and DNA repair factor
CC       IIH (TFIIH) core complex, which is involved in general and
CC       transcription-coupled nucleotide excision repair (NER) of damaged DNA
CC       and, when complexed to CAK, in RNA transcription by RNA polymerase II.
CC       In NER, TFIIH acts by opening DNA around the lesion to allow the
CC       excision of the damaged oligonucleotide and its replacement by a new
CC       DNA fragment. In transcription, TFIIH has an essential role in
CC       transcription initiation. When the pre-initiation complex (PIC) has
CC       been established, TFIIH is required for promoter opening and promoter
CC       escape. Phosphorylation of the C-terminal tail (CTD) of the largest
CC       subunit of RNA polymerase II by the kinase module CAK controls the
CC       initiation of transcription. {ECO:0000256|RuleBase:RU368090}.
CC   -!- SUBUNIT: Component of the 7-subunit TFIIH core complex composed of XPB,
CC       XPD, TFB1/GTF2H1, GTF2H2/P44, TFB4/GTF2H3, TFB2/GTF2H4 and TFB5/GTF2H5,
CC       which is active in NER. The core complex associates with the 3-subunit
CC       CDK-activating kinase (CAK) module composed of CYCH1/cyclin H1, CDKD
CC       and MAT1/At4g30820 to form the 10-subunit holoenzyme (holo-TFIIH)
CC       active in transcription. {ECO:0000256|RuleBase:RU368090}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU368090}.
CC   -!- SIMILARITY: Belongs to the TFB4 family. {ECO:0000256|ARBA:ARBA00005273,
CC       ECO:0000256|RuleBase:RU368090}.
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DR   RefSeq; XP_016486790.1; XM_016631304.1.
DR   AlphaFoldDB; A0A1S4BCY3; -.
DR   STRING; 4097.A0A1S4BCY3; -.
DR   PaxDb; 4097-A0A1S4BCY3; -.
DR   GeneID; 107807025; -.
DR   KEGG; nta:107807025; -.
DR   OMA; CFCHRKV; -.
DR   OrthoDB; 45434at2759; -.
DR   Proteomes; UP000084051; Unplaced.
DR   GO; GO:0000439; C:transcription factor TFIIH core complex; IBA:GO_Central.
DR   GO; GO:0005675; C:transcription factor TFIIH holo complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008353; F:RNA polymerase II CTD heptapeptide repeat kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IBA:GO_Central.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR004600; TFIIH_Tfb4/GTF2H3.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR12831:SF0; GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3; 1.
DR   PANTHER; PTHR12831; TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED; 1.
DR   Pfam; PF03850; Tfb4; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU368090};
KW   DNA repair {ECO:0000256|RuleBase:RU368090};
KW   Metal-binding {ECO:0000256|RuleBase:RU368090};
KW   Nucleus {ECO:0000256|RuleBase:RU368090};
KW   Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU368090};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU368090}; Zinc {ECO:0000256|RuleBase:RU368090};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU368090}.
FT   REGION          271..291
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   291 AA;  32061 MW;  E920BADC0B157F3E CRC64;
     MTPVSSKLYT DDVSLLMVLI DTNPYLWSSM KNTAFTFSKF LSHVLAFLNS ILLLNQMNQV
     VVIATGYNSC DYVFDSSSSS MQRAECLLEK LEEFVDKDET LSQEDSVDGV GFSLLSGSLS
     MALCYIQRVF RTGPLHPQPR ILCLHGSPDG PGQYVAVMNA IFSAQRSMVP IDSCVIGSQH
     SAFLQQASYI TGGVYLKPQV SDGLFQYLST VFATDLHSRA FLQLPRPVGV DFRASCFCHK
     NTIDMGYICS VCLSIFCKHH KKCSTCGSNF GEARKQDPSA SGQRRKTPDG S
//
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