ID A0A1S4BJ18_TOBAC Unreviewed; 738 AA.
AC A0A1S4BJ18;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=DNA mismatch repair protein MLH1 {ECO:0000313|RefSeq:XP_016488883.1};
GN Name=LOC107808834 {ECO:0000313|RefSeq:XP_016488883.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016488883.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016488883.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR RefSeq; XP_016488883.1; XM_016633397.1.
DR AlphaFoldDB; A0A1S4BJ18; -.
DR SMR; A0A1S4BJ18; -.
DR STRING; 4097.A0A1S4BJ18; -.
DR PaxDb; 4097-A0A1S4BJ18; -.
DR GeneID; 107808834; -.
DR KEGG; nta:107808834; -.
DR OMA; ANYHVKK; -.
DR OrthoDB; 5475669at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0032389; C:MutLalpha complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03483; MutL_Trans_MLH1; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051}.
FT DOMAIN 238..355
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 381..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 738 AA; 82626 MW; E25289CBF6416649 CRC64;
MEIEEAINEV EMEPIAAAAA AIPKEPPKIK RLEESVVNRI AAGEVIQRPV SAVKELIENS
LDANSTSISV VVKDSGLKLI QVSDDGHGIR YEDLPILCER HTTSKLSKFE DLQTISSMGF
RGEALASMTY VGHVTVTTIT DGQLYGYRAT YRDGLMVDEP KPCAAVKGTQ IMIENLFYNM
AARRKTLENS SADDYPKIVD LISRFAIHHI NVSFSCRKHG AGRADVYSLA TCSRIDSIRS
VYGVSVARNL MKIEVSDTGF KMDGFISDSN YIAKKITMVL FINDRLVDCS ALKRAIEIVY
TATLPKASKP FIYMSIVLPP QHVDVNVHPT KREVSLMNQE FIIEKIQSVV ESKLRSSNES
RRFQEQTMDF CSSSPVATIK DSSKDCPSSS GIKSQKAPHK MVRTDTLDPS GRLHAYMQMK
PPSNSERGGS CLSSVRSSIR QRRNPSETAD LTSIQELVNE IEIDCHPGLL DVVRHCTYIG
MADEVFALIQ HNTHLYLVNV INLSKELMYQ QVLRRFAHFN AIQLSEPASL PELIMLALKE
EEGLDPQGNE SNELRGKIAE MNTELLKEKA EMLGEYFSVY IDSNGNLSRL PVILDQYTPD
MDRIPEFILC LGNDVDWEDE KVCFQTIAAA LGNLYAMHPP LLPKPSGDGL KFYRKRMLSS
GSVGTYMENI ENDTAESEFE AELLLEAENA WAQREWSIQH VLFPSLRLFS KPPASMAKNG
TFVQVASLEK LYRIFERC
//