ID A0A1S4BJ27_TOBAC Unreviewed; 1009 AA.
AC A0A1S4BJ27;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC107808843 {ECO:0000313|RefSeq:XP_016488893.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016488893.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016488893.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_016488893.1; XM_016633407.1.
DR AlphaFoldDB; A0A1S4BJ27; -.
DR SMR; A0A1S4BJ27; -.
DR PaxDb; 4097-A0A1S4BJ27; -.
DR GeneID; 107808843; -.
DR KEGG; nta:107808843; -.
DR OMA; HVVKIAF; -.
DR OrthoDB; 991910at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14066; STKc_IRAK; 1.
DR Gene3D; 2.60.120.430; Galactose-binding lectin; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021720; Malectin_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR48006; LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED; 1.
DR PANTHER; PTHR48006:SF72; LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE RFK1-RELATED; 1.
DR Pfam; PF00560; LRR_1; 3.
DR Pfam; PF11721; Malectin; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|RefSeq:XP_016488893.1};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_016488893.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|RefSeq:XP_016488893.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1009
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010350056"
FT TRANSMEM 608..631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 666..939
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 986..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1009 AA; 112883 MW; 553A52B2959841CE CRC64;
MLTAKRDVLS WILVVNYFLL LNLGESRVAQ EEVDILEQIA VTMGATHWKF NGELCQIEAV
MVTTDRPNWS ETDVKCNCSI GNDTLCHVVA ITLKGISLPG VLPPELVKLP YIQQVDFAYN
YLSGSIPAEW ASTPLSFISV LVNRLSGEIP KELGNITSLT YINLEGNQFS GIIPSELGKL
INLKTLILSS NQLEGELPTS LSGLVNLTDF RISDNNVSGP IPDFIQNWKQ LAKLELHASG
LEGPIPSGIS LLNMLTDLRI SDINGPMQEF PPLNNMTGLV ILVLRNCNLS GVIPGYIWQL
KTIQTFDVSF NKLVGTIPDD ISARTMLKFV FLSGNMLSGN VPDSILKNGI NVDLSYNNFT
WQGPDQPACR QNTNYYINLY KSSSAVSILR NVLPCTEDLT CPRYGCSLHV NCGGNDFTVK
ENNRQLDYEG DAQVEGGSAR YFRSNKYWGF SSTGDFMDDA NDQNTRFIES TQSLSELYSG
ARASPLSLTY FRYCLENGNY SVSLHFAEIM FKDDRTYYNL GRRVFDIYIQ EKLVWKDFNI
EEEARGVKRP VIRRFNATVT DSVLEIRLYW GGKGTTRIPL RGHYGALISA ISVDSNFKFC
SNKDRKTVII YVIVGVLAAC ITFFVLSILW WKGYLCRERK RRDLNGVELQ MVCFTLKQIK
AATKNFDASN KIGEGGFGPV YKGQLPDGTL VAVKQLSSQS KQGNREFLNE ISTISCLQHP
NLVKLHGCCI EADQLLLVYE YLDNNSLAGA LFEDSRLTLD WPTRFRICLG IAKGLAFLHE
ESSLKIVHRD IKATNVLLDG QLNPKISDFG LARLNEEEKT HISTRVAGTI GYMAPEYALW
GYLTDKADVY SFGVVLLETV SGKNNNNYMP SNHSICLLDW ACHLQQSGSI EELIDQRLDS
DINKQEVERI VKVALLCTSA TPSLRPIMSE VVSMFEGRLA IPDEIPEANT YSNDLRFKAM
KDFHQERQKQ KLTGSQTQNT MTIQTDMGSS SASTTNLFDS VQFQDQTDT
//
