ID A0A1S4BP94_TOBAC Unreviewed; 1780 AA.
AC A0A1S4BP94;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Brefeldin A-inhibited guanine nucleotide-exchange protein 2-like {ECO:0000313|RefSeq:XP_016490661.1};
GN Name=LOC107810397 {ECO:0000313|RefSeq:XP_016490661.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016490661.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016490661.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR RefSeq; XP_016490661.1; XM_016635175.1.
DR SMR; A0A1S4BP94; -.
DR STRING; 4097.A0A1S4BP94; -.
DR PaxDb; 4097-A0A1S4BP94; -.
DR GeneID; 107810397; -.
DR KEGG; nta:107810397; -.
DR OMA; DDHRYFW; -.
DR OrthoDB; 296747at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032629; DCB_dom.
DR InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR032817; Mon2_C.
DR InterPro; IPR046455; Sec7/BIG1-like_C.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF375; LD29171P; 1.
DR Pfam; PF20252; BIG2_C; 1.
DR Pfam; PF16213; DCB; 1.
DR Pfam; PF16206; Mon2_C; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF09324; Sec7-like_HDS; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 607..794
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 44..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1301..1327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1780 AA; 198781 MW; 6663E72EA63AFB9D CRC64;
MASSEADSRL NQVLLPALEK IIKNGSWRKH SKLSHECKSV IEFLTNPSSS TPPTSPSAQP
DPDTTNQHPG VLLDLSFNDS ELILSPLINA AVSGHLKIAE AALDAVQKLI AHGYLRGEAD
PTGGPDAKLL SKLIESVCKC HDLGDDAVEL LVIKTILSAV TSVSIRIHGD SLLQVVRTCY
DIYLESKNVV NQTTAKASLV QMLVIVFRRM EADSSTVPLQ PIVVAELMEP AEKADADGSM
TLFVQGFITK VLQDIDGVFN TGTPRAGATS TGAHDGAFET TTSTVESTNP ADLLDSTDKD
MLDAKYWEIS MYKTALEGRK GELVDGEGER DDDLEVQIGN KLRRDAFLVF RALCKLSMKT
PPKEAAADPQ LMRGKIVALE LLKILLENAG AIFRTSDRFL GAIKQYLCLS LLKNSASSLM
IVFQLSCSIF ISLVARFRGG LKAEIGVFFP MIVLRVLENV AQPNFQQKMI VLRFLERLCI
DSQILVDIFL NYDCDVNSSN IFERMVNGLL KTAQGVPPGT TTTLLPPQEA TMKLEAMKCL
VAILKSLGDW MNKQLRIPDT HSTKKYEAHD SNSEPGTLPI ANGNEDEHTE VSDSHSESSS
EVSDVSTIEQ RRAYKLELQE GISLFNRKPK KGIEFLINAN KVGSSPEEIA AFLKDASGLN
KTLIGDYLGE RDDLALKVMH AYVESFDFQG KEFDEAIRAF LQGFRLPGEA QKIDRIMEKF
AERYCKCNPK AFSSADTAYV LAYSVILLNT DAHNPMVKTK MSADDFLRNN RGIDDGKDLP
EDYLRSLYER ISRNEIKMKD DNLALQQKQS LNSNRILGLD SILNIVVRKR GDGSMETSDD
LVRHMQEQFK EKARKSESVY YAATDVVILR FMVEVCWAPM LAAFSVPLDQ TDDGVVIALC
LEGFRCAIHV TAAMSMKTHR DAFVTSLAKF TSLHSPADIK QKNIEAIKAI VTIADEDGNY
LQEAWEHILT CVSRFEHLHL LGEGAPPDAT FFALPQNEFD KSKQTKSSIL PVLKKKGPGK
IQSAAAAMRR GSYDSAGIGG SAAAGITSEQ MNNLVSNLNM LEQVGEMNRI FIRSQKLNSE
AIVDFVKALC KVSMEELRST SDPRVFSLTK MVEIAHYNMN RIRFVWTKIW QVLGEFFVTI
GCSENLSIAI FAMDSLRQLS MKFLEREELA NYNFQNEFMK PFVIVMRKSS AVEIRELIIR
CVSQMVLSRV NHVKSGWKSM FMVFTTAAYD DHKNIVLLSF EIMEKIVRDY FPYITETETT
TFTDCVNCLI AFTNSRFNKD ISLNAIAFLR LCAAKLAEGD LGSSRNKDKE ASGKPSPSSP
HKEKDHNIEN GELTDKEDHL YFWFPLLAGL SELSFDPRPE IRKSALQVLF DTLRNYGHHF
SLSLWERVFE SVLFPIFDYV RHTIDPSGEN SPMHGNDDEE GEPDQDAWLY ETCTLALQLV
VDLFVKFYDT VNPLLKKVLF LLVNFVKRPH QSLAGIGIAA FVRLMSNAGN LFSEDKWLEV
VLSLKEAANA TLPDFSFLLN ENNNYWSQEE DMARNSNAET IGTDSPDEDL ENLRRHRLYE
AISDVKCRAA VQLLLIQAVM EIYNIYRPQL SSKNIIVLFD AMRGVASHAH KINSDATLRS
KLLEFSSMTQ MQDPPLLRLE NEAYQICLSF LQNLVQDKPT GFEDSEVETY LVNLCSEVLH
FYIEIARSRQ MSESSLGAQL RWLIPLGSGR RRELAARAPL IIATLQAICS LGDASFEKNL
SCFFPLLSSL ISCEHGSSEI QLALSDMLSS SVGPVLLRSC
//
