ID A0A1S4BUD0_TOBAC Unreviewed; 543 AA.
AC A0A1S4BUD0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Exonuclease 1-like isoform X1 {ECO:0000313|RefSeq:XP_016492485.1};
GN Name=LOC107811994 {ECO:0000313|RefSeq:XP_016492485.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016492485.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016492485.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_016492485.1; XM_016636999.1.
DR AlphaFoldDB; A0A1S4BUD0; -.
DR SMR; A0A1S4BUD0; -.
DR STRING; 4097.A0A1S4BUD0; -.
DR PaxDb; 4097-A0A1S4BUD0; -.
DR GeneID; 107811994; -.
DR KEGG; nta:107811994; -.
DR OMA; KLEMSCI; -.
DR OrthoDB; 126305at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0035312; F:5'-3' DNA exonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0017108; F:5'-flap endonuclease activity; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR CDD; cd09901; H3TH_FEN1-like; 1.
DR CDD; cd09857; PIN_EXO1; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR044752; PIN-like_EXO1.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR019974; XPG_CS.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR11081:SF72; 5'-3' EXONUCLEASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS00842; XPG_2; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000313|RefSeq:XP_016492485.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051}.
FT DOMAIN 1..102
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 141..216
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
SQ SEQUENCE 543 AA; 61474 MW; CADDEA9E54B7E29D CRC64;
MGIKDLLRFM KPYVESVHIK KYAGKRVGID AYSWLHKGAY SCSMELCLNL EGDKKLQYLN
YFMHRINLLR HYKITPVVVF DGGNLPCKSR TEDERHRRRK TNRDQAMLKL KEGNVAGAVE
LFQRAVSVTP SMAHQLIQIL KSENIEFVVA PYEADAQLAY LSSLEEEKSG IVAVISEDSD
LLAYGCPAVF FKMDSHGNGQ EVELDRVFSS ATLVPSFRHF NQDLFTGMCV LAGCDFLPSV
PGIGIAKAYN LVSKYRNLDR VLSILKFEKG DQVPEDYTKS FKEAVAVFHH ARIYDVSLKR
TKHLKPVPEQ LLQFLDEELD FLGPEILPSL ATAIAQGSID PCTMEAFDFF PNMVNHVSTA
NVKKICGPFS RQQASAQASK DCSFLAISSS KTRKETTVVE TKQTSDEQKQ CPFMDDRECI
EEAVALQNLL CPSISTRKTV GKEKKSRQKE VLKVPDNNPF RKRKVEEIEP DELESVTEQI
SEVTEVESLE VVCTTPESQR SVESKPIKRI ELRKVTNERK VKRSNCQSSE NKKNSILNFF
SRV
//
