ID A0A1S4BUP1_TOBAC Unreviewed; 525 AA.
AC A0A1S4BUP1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Protein DETOXIFICATION {ECO:0000256|RuleBase:RU004914};
DE AltName: Full=Multidrug and toxic compound extrusion protein {ECO:0000256|RuleBase:RU004914};
GN Name=LOC107812068 {ECO:0000313|RefSeq:XP_016492587.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016492587.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016492587.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199,
CC ECO:0000256|RuleBase:RU004914}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_016492587.1; XM_016637101.1.
DR AlphaFoldDB; A0A1S4BUP1; -.
DR SMR; A0A1S4BUP1; -.
DR STRING; 4097.A0A1S4BUP1; -.
DR PaxDb; 4097-A0A1S4BUP1; -.
DR GeneID; 107812068; -.
DR KEGG; nta:107812068; -.
DR OMA; RIAMHLG; -.
DR OrthoDB; 10858at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR PANTHER; PTHR11206:SF299; PROTEIN DETOXIFICATION; 1.
DR Pfam; PF01554; MatE; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU004914};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Transmembrane {ECO:0000256|RuleBase:RU004914};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004914}.
FT TRANSMEM 141..158
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 178..195
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 207..230
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 236..257
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 278..303
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 309..336
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 357..378
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 398..421
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 428..452
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 458..479
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT NON_TER 525
FT /evidence="ECO:0000313|RefSeq:XP_016492587.1"
SQ SEQUENCE 525 AA; 57076 MW; 845783E367096CFC CRC64;
MNKPWKKAAE LQNQSEDSDF WLNTYSSDHN HLVGADGDYR PAKSFKDWWA IFCIETVKLW
RIGGPIAFKI ICQYGVNSLT NIFVGHLGNI ELSAISIAET VISTFSFGFM MGMGSALETL
CGQAYGAGQV HMLGVYMQRS IIILLATCVI LLPIYLFATP VLELLGQEIA IAKLAGRYTM
LIILQVFSLA INFPTSKFLP AQSKVDVLAG IGFAALLVHA LFLWLFIYTF GWGTTGAAIA
FDLTSWLTAI AQLGYVVGWC KDGWKGLSWA AFNEIWAFVR LSIASAVMLC LEVWYMMSII
LLVGHLNNAV IAVGSISICI NINGWENMLF IGINAAMSLR VSNELGQGHP RATKYSVYIA
VLQCFLIGIL CMVIVLLARN HLAIIFSSSK DMQEAVGGLA FLLGITMVLN SVQPVISGVA
IGGGWQALVA YINLGCYYLF GLPLGYVLGY VAKMGIRGLW LGMIAGAALQ TLVLLIILYK
TNWSTEQKPE LEMDCCGPGV TAVGPRQKAV ADSERLVGRG PGITA
//
