ID A0A1S4BX85_TOBAC Unreviewed; 687 AA.
AC A0A1S4BX85;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=BRCA1-associated RING domain protein 1 {ECO:0000313|RefSeq:XP_016493384.1};
GN Name=LOC107812739 {ECO:0000313|RefSeq:XP_016493384.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016493384.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016493384.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016493384.1; XM_016637898.1.
DR AlphaFoldDB; A0A1S4BX85; -.
DR SMR; A0A1S4BX85; -.
DR STRING; 4097.A0A1S4BX85; -.
DR PaxDb; 4097-A0A1S4BX85; -.
DR GeneID; 107812739; -.
DR KEGG; nta:107812739; -.
DR OMA; NTICAFC; -.
DR OrthoDB; 318045at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0070531; C:BRCA1-A complex; IBA:GO_Central.
DR GO; GO:0031436; C:BRCA1-BARD1 complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IBA:GO_Central.
DR GO; GO:0035067; P:negative regulation of histone acetylation; IBA:GO_Central.
DR GO; GO:0035066; P:positive regulation of histone acetylation; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd17734; BRCT_Bard1_rpt1; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR031099; BRCA1-associated.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR13763:SF7; BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1; 1.
DR PANTHER; PTHR13763; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00292; BRCT; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 28..66
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 302..422
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 467..552
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 573..687
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 180..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 76049 MW; 960909C7C95C255F CRC64;
MAAETQSISR LLNPLAFHIQ KLGLELKCPL CLNLLNKPML LPCDHIFCNL CVPRSTQVQC
ECPVCKHQYV NQEIRAVPHV ESMIAIFRSL DATFNAKVFQ FKSPDAGWSS EQYPISVNLD
DKSRNEQTVK AIVSSNDPNK EINRCNGHGI PWNGVSHLSL LPSSDRKADL KNERNIAEEI
DLNQLQQQSP GSSHSSDNNK DIVKETSELR VRNNDIKSHT AKMSVEDSSH VVEGLVHHTI
KHEHVFEERD LKRQKKLSYE LSETVLQSHA ITNSDRSLAC KLSESSLVAQ PKAVSDQHLP
KGSVCAFCHT SKITEGTGPM LHYANGREVV GDVTSLSKAI PVHMKCIDWA PQVYYDGDTL
RNLEAELARA AKLKCSGCGL KGAALGCLMK SCRRSYHMPC AFEIQDCRWD CDNFVMLCPS
HKSVKFPSEK SKSRKRASME ACPESAPITS ERLNFWATSS DGPKEWVLCG SALSSEEKYM
MVKFANMCGA TVCKTWNPNV THVIAATDEK GACTRTLKVL MAILGGKWIL TIDWIKACIG
ANCPVIEEPY EVSLDNHGCF GGPKAGRLKA SSNAPKLFDG FKFYLSGDYV AAYKKDLLDL
VEKGGGSIIH SKEQLIYQIG SMKATNSSCL VVYNLDPPRG CMSGEDSNVL LHRQAEAEDL
AKQIGCQVIQ HTWILQSIAA CKLEPFC
//
