ID A0A1S4C3P9_TOBAC Unreviewed; 1167 AA.
AC A0A1S4C3P9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN Name=LOC107814753 {ECO:0000313|RefSeq:XP_016495687.1,
GN ECO:0000313|RefSeq:XP_016495688.1, ECO:0000313|RefSeq:XP_016495689.1,
GN ECO:0000313|RefSeq:XP_016495690.1, ECO:0000313|RefSeq:XP_016495691.1,
GN ECO:0000313|RefSeq:XP_016495692.1, ECO:0000313|RefSeq:XP_016495693.1,
GN ECO:0000313|RefSeq:XP_016495694.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016495689.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016495687.1, ECO:0000313|RefSeq:XP_016495688.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_016495687.1; XM_016640201.1.
DR RefSeq; XP_016495688.1; XM_016640202.1.
DR RefSeq; XP_016495689.1; XM_016640203.1.
DR RefSeq; XP_016495690.1; XM_016640204.1.
DR RefSeq; XP_016495691.1; XM_016640205.1.
DR RefSeq; XP_016495692.1; XM_016640206.1.
DR RefSeq; XP_016495693.1; XM_016640207.1.
DR RefSeq; XP_016495694.1; XM_016640208.1.
DR STRING; 4097.A0A1S4C3P9; -.
DR PaxDb; 4097-A0A1S4C3P9; -.
DR GeneID; 107814753; -.
DR KEGG; nta:107814753; -.
DR OMA; CANGNEA; -.
DR OrthoDB; 952768at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF600; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 11..183
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1167 AA; 133216 MW; E134B75622C0D1FB CRC64;
MDSQKELNKK WEYDAFLSFR GEDTRNNFVA HLHKRLEERG VNVFKDDEKL ERGRPISAEL
LKAIEESRVA IIIFSKNYAS SVWCLEELTK LMECVEKKGQ EAIPIFYNVD PSDVRMQRSK
SSFAKAMAKH KANFEGNDLE KVQRWTDALQ KAANIAGWDL GKCANGNEAE CIDRIVHEKF
QNVHHTVSAT EKYLVGVESR TGGVESMLKV GSGGVYFVGI WGMGGVGKTT VARKIFDNIS
NQFQGSCFLA NVREESKKHG IKHLQKTLLS RILNEKSLKV ASFYEGADML KGKFCLRKVL
IVFDDVDDNH QLEYLVGKHD WFGDGSRIVT TTRNADLLRC HDELYSVPEL AKCEALELFS
WHAFQKRTPD KEFLKLSKSV VDYAKGLPLA LTVLGSFLYK RGITEWGSAL DRLKDTGYEE
IVKQLSLSVD GLSYEDKNIF LDIACFFRGK RRDFVITILN SFGFKSEIGI DVLTKKSLLY
ISEGMVEMHD LIEQMGQQLA RDVDQDKPWN HSRIWHENDI ETVFSANRWT ESVKGIMVPI
GSDRHICKWS KAFRNMPCLR LLMVKGEEVR HYEQVSDTIE YLPSSLKWLD WSYYSFESLP
TNFQPRNLVG LNMTFSSLVE ICKEPKAFVK LTILNLSFSE NLLRTPNFSE IPNLQRIILK
SCLSLKDVHP SIGNLKKLVS LNMKNCKNLK FLPSSIQMES LECLNLSGCE KLDTLPEIRG
NMELLSELLL GRTAIRELPS SIGRLFGISL LDLHSCENLV RLPASVSEMR KLKVLILKGC
LKLATFPESL GDLEELEELY AGNTAVWRLP DSMENLSKLK ILSLKGRREM KCQSATGLIF
PCAFHGLRAL KSLDLSGCNL SGDEINGLTC LTSLLELNLS RNKFISLPDG ISQLYQLRYL
NITHCHELKK LPKLPPSIKE LYSEDFLAKQ IILAMSVYRG LCLASFTNYS FDQQPYTEKS
DDNSVLDEIL SLFLSDSMDD KMTYCIIFPE RAIPTWFKHQ STEEKILLKL PEDWYDDRFE
GFAICCVTCM GAGVHDPDSG LSGKYDYTFI KAKLICNNHM EELEVLEKEC KVSTTSRTYS
WCVCFAYIPL YSLLQTSGTQ VLNFNQYGLF EASIQRHITR QWGVHLIYKS ERQFFESRTE
KGLLAQKLSL VKPIRVKTRI VRLELPK
//