ID A0A1S4C7J8_TOBAC Unreviewed; 670 AA.
AC A0A1S4C7J8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=TMV resistance protein N-like isoform X1 {ECO:0000313|RefSeq:XP_016497108.1, ECO:0000313|RefSeq:XP_016497109.1};
GN Name=LOC107815978 {ECO:0000313|RefSeq:XP_016497108.1,
GN ECO:0000313|RefSeq:XP_016497109.1, ECO:0000313|RefSeq:XP_016497110.1,
GN ECO:0000313|RefSeq:XP_016497111.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016497110.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016497108.1, ECO:0000313|RefSeq:XP_016497109.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016497108.1; XM_016641622.1.
DR RefSeq; XP_016497109.1; XM_016641623.1.
DR RefSeq; XP_016497110.1; XM_016641624.1.
DR RefSeq; XP_016497111.1; XM_016641625.1.
DR STRING; 4097.A0A1S4C7J8; -.
DR PaxDb; 4097-A0A1S4C7J8; -.
DR GeneID; 107815978; -.
DR KEGG; nta:107815978; -.
DR OrthoDB; 5491060at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF393; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 3.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..89
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 670 AA; 76881 MW; 9C67339FC0C0DEAF CRC64;
MECKDQCGQT VIPVFYDVDP LHVRNQRESF AEAFDKHETR YKDDDEGMQK LQRWRSALTA
AANLKGYDVR DGIEAENIQK IIDQISKLCN SATLSSLRDV VGIETHLEKL KSLLKVGIND
VRIILGMWGM GGVGKTTIAR AIFDTLSHQF EAACFLADIK ENEKLHSLQN TLLSKLLRRK
DDYVNNKHDG KRMISDRLCS KKVLIVLDDI GHKDHLEYLA GDIGWFGNGS RVIVTTRDKH
LIGKDDSIYE VTALPDHESI QLFHQHAFKK EVPDECFKEL SLKGTMAMEA IWLHDNFGTL
RFSNEAMKNM KRLRILYIER WSCYGSIEYL SNNLHWLVLD GYPCESLPST FEPKMLVHVQ
LKHNSLHYLW METKHLPSLK KLILSGSGNL MRTPDFKGMP NLEYLDLSFC SNFEELHDTL
GCCRKLVELN LTWCERLKRF PCVNVESLEY LSLENCSSLE KFPEIHGRMK PKIQIHMLGS
GIRELPSSYF QYQTHITELD LSFMRNLVAL PSSISRLKSL VSLSVLDCSK LESLPEDIGS
LSSLKELYLN GNNFEHLPRS IAQLGALRSL DLSYCQRLTQ LPELPPELNE LHVDCHMALK
FIHDLVTKRK KLQRVIFPDD EDDALDDPIY NLFAHALFQN ISSLRHHISA SDSLSESVFT
ILHPWKKIPS
//
