ID A0A1S4CEP7_TOBAC Unreviewed; 559 AA.
AC A0A1S4CEP7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Reticulon-like protein {ECO:0000256|RuleBase:RU363132};
GN Name=LOC107818175 {ECO:0000313|RefSeq:XP_016499608.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016499608.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016499608.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363132}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU363132}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR RefSeq; XP_016499608.1; XM_016644122.1.
DR AlphaFoldDB; A0A1S4CEP7; -.
DR SMR; A0A1S4CEP7; -.
DR STRING; 4097.A0A1S4CEP7; -.
DR PaxDb; 4097-A0A1S4CEP7; -.
DR GeneID; 107818175; -.
DR KEGG; nta:107818175; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003388; Reticulon.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR Pfam; PF02453; Reticulon; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS50845; RETICULON; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU363132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363132};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363132}.
FT TRANSMEM 396..429
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363132"
FT TRANSMEM 490..523
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363132"
FT DOMAIN 379..559
FT /note="Reticulon"
FT /evidence="ECO:0000259|PROSITE:PS50845"
SQ SEQUENCE 559 AA; 61562 MW; C8C96A779F6A98C7 CRC64;
MGEGEERWCV VTGGRGFAAR HLVEIRYEMF HVRIADLCPD IKLEPDEEEG TVGKALRSGR
AHYVSMDLRD KSQVLKVCEG AEVVFHMAAP DSSINNHQLH HSVNVLGTKN VIDACVELKV
KRLIYTSSPS VVFDGVHGIL NGDESLPYPA QHNDSYSATK AEGEALVIKS NDSKGLLTCC
IRPSSIFGPG DRLLVPSLVA AARTGKSKFI IGDGNNMYDF TYVENVAHAH VCAERALASG
GAVAEKAAGQ AYFITNMEPI KFWEFVSLIL EGLGYERPSI KIPASVMMPI AHLVELAYKL
LAAYGMKVPQ LTPSRIRLLS RSRTFSCSKA NDRLGYTPIV PLQEGLRRTI ESYPHLRAEK
RPEKEGPSKA SLFLGSGRVA DTLLWKDKKQ TLTAALVLAA IYFNFVASGF TVVTSISRIL
FVASIFLFIH GRLPQKIMGY KIDKVPGSCF HVSAETSRQV ALSAASGWNS AVKGLKSLCR
GTDCMFFLKV VLSLLILCIL GTISLRSLFV IGIPAAFTLF FIYEKKEEEI DHLLHEIISF
TWKLKSDISR RIFSSANDL
//
