ID A0A1S4CGT5_TOBAC Unreviewed; 376 AA.
AC A0A1S4CGT5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Cysteine proteinase COT44-like {ECO:0000313|RefSeq:XP_016500184.1};
GN Name=LOC107818652 {ECO:0000313|RefSeq:XP_016500184.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016500184.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016500184.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR RefSeq; XP_016500184.1; XM_016644698.1.
DR AlphaFoldDB; A0A1S4CGT5; -.
DR SMR; A0A1S4CGT5; -.
DR STRING; 4097.A0A1S4CGT5; -.
DR PaxDb; 4097-A0A1S4CGT5; -.
DR GeneID; 107818652; -.
DR KEGG; nta:107818652; -.
DR OMA; LMFIDEH; -.
DR OrthoDB; 5472443at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF951; CATHEPSIN-RELATED; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..376
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016955460"
FT DOMAIN 52..109
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 142..357
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 376 AA; 42451 MW; C06EA16FE8F7D66E CRC64;
MAKTIITTLL FALFSSLSYA IDMSIIDYKN NQHVGNMKKW TWQNDEEVKG IYELWLAEHG
KAYNALGEKE KRFEIFKDNL KFIEEHNNSG NRTYKVGLNQ FADLTNEEYR TMYLGTRSDA
RRRFVKSKNP SHRYASRPNE LMPHSVDWRK RGAVAPIKNQ GSCGSCWAFS TVAAVEGINQ
IVTGEMITLS EQELVDCDRV QNSGCNGGLM DYAFEFIISN GGIDTENHYP YCGVEGRCDP
VRKNYKVVSI DGYEDVPRNE RALQKAVAHQ PVCVAIEASG RAFQHYSSGV FTGECGEQVD
HGVVVVGYDS EDGVDYWIVR NSWGTKWGEN GYVKMERNVK KSHLGKCGIM TEASYPTKDS
GINKRTTSNE EKISSI
//
