ID A0A1S4CPE8_TOBAC Unreviewed; 1175 AA.
AC A0A1S4CPE8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=LOC107821048 {ECO:0000313|RefSeq:XP_016502940.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016502940.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016502940.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_016502940.1; XM_016647454.1.
DR AlphaFoldDB; A0A1S4CPE8; -.
DR GeneID; 107821048; -.
DR OMA; HLQIMKD; -.
DR OrthoDB; 1114285at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF153; ATP-DEPENDENT DNA HELICASE Q-LIKE 4A; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_016502940.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051}.
FT DOMAIN 454..629
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 654..808
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 669..711
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 1014..1096
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 988..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1094..1146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1175 AA; 131575 MW; 2164F357CC1FD91A CRC64;
MSKDKLPKVN WTQHATAHEN FSCQDKFLTS NFLFSLPTQK PCVREQMNAR SMACQVRSAT
KLETEKAWKL LNSLKLSSKS YTRPGKTLPL TKDNKSFSQH SHNTHVLRAS DVNYASARCT
PLHQGVDENS EYSDTTRYAG NRFPSHSSGG AEIGKVVNRQ NGADTSLANN SHSRGIGGIS
SNHAIGVSKT REYNNTCADG TDEDDILQNI DIDQIVEHYQ TNCTPQPSVS RCPPITPFTD
SKCLAGSEET NLPPELSLNC NHGLKLGLCP EALDHLQEMK DRLINISNDL LDNVSELSLE
QVEMLRQERS QLKLQIQHLE KFLQTVSGNE ERRMSQFSAS TQTSAFQYET PRAGSSRIDP
IRLDTQFHGY NESGGFGNWN SSSLSFDVTG GFGLSTAPVE REPYIPKYLE VKYTEGSNDK
KWSSRDFPWT KKLEADNKKV FGNPSFRPNQ REVINATMSG CDVFVLMPTG GGKSLTYQLP
ALICPGITLV ISPLVSLIQD QIMHLLQVNI PAAYLSSNME WTEQQEILRE LNSDVCKYKF
LYVTPEKVAK SDVLLRHLES LHTRESLARI VIDEAHCVSQ WGHDFRPDYQ GLGILKQKFP
TVPVLALTAT ATMSVKEDVV QALGLANCII FRQSFNRPNL RYSVIPKTKK CLEDIDNFIK
KFHFDQCGII YCLSRMDCER VAEKLQEYGH KAAFYHGSME GAQRANIQKQ WSKDEINIIC
ATVAFGMGIN KPDVRFVIHH SLPKSIEGYH QECGRAGRDG LPSSCVLYYS YSDYIRVKHM
ISQGTVDQNS FGSGYGRSNV ATSGRILETN VENLLRMVSY CENDVDCRRL LQLIHFGEKF
ESTNCRKTCD NCSKIQKCIE KDVTEVAKQL VELVKMTGQK FSSAHVLEVY RGSLSQYVKK
HRHESLRLHG AGKHLAKGEA SRVLRHLVTE DILVEDVKKS DLYGSVSSVL KVNESKAYNL
FSGAQTMRLR LPSSVTQSKL GKFEATPAKV SLTSGKQSPP RTDPSAAPQS PVDTNLSAKL
YTALRRLRTL LVKEAGDGVM AYHIFGDATM QQISIKVPRT TDELLDINGI GKVKIIKYGD
RVLETIEATI NEHKSVKTNS SGNDSTDSGK KRRNSINVQN ANSKDEEDFT GSTGRSKKRV
SKKQNKNPEV IDYRDLGYFD ECMDGDIDFD ETMMP
//
