ID A0A1S4CPM3_TOBAC Unreviewed; 840 AA.
AC A0A1S4CPM3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Beta-adaptin-like protein {ECO:0000256|PIRNR:PIRNR002291};
GN Name=LOC107821274 {ECO:0000313|RefSeq:XP_016503188.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016503188.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016503188.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Subunit of clathrin-associated adaptor protein complex that
CC plays a role in protein sorting in the late-Golgi/trans-Golgi network
CC (TGN) and/or endosomes. The AP complexes mediate both the recruitment
CC of clathrin to membranes and the recognition of sorting signals within
CC the cytosolic tails of transmembrane cargo molecules.
CC {ECO:0000256|PIRNR:PIRNR002291}.
CC -!- SUBUNIT: Adaptor protein complexes are heterotetramers composed of two
CC large adaptins (beta-type subunit and alpha-type or delta-type or
CC epsilon-type or gamma-type subunit), a medium adaptin (mu-type subunit)
CC and a small adaptin (sigma-type subunit).
CC {ECO:0000256|PIRNR:PIRNR002291}.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000256|ARBA:ARBA00006613, ECO:0000256|PIRNR:PIRNR002291}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_016503188.1; XM_016647702.1.
DR AlphaFoldDB; A0A1S4CPM3; -.
DR SMR; A0A1S4CPM3; -.
DR STRING; 4097.A0A1S4CPM3; -.
DR PaxDb; 4097-A0A1S4CPM3; -.
DR GeneID; 107821274; -.
DR KEGG; nta:107821274; -.
DR OMA; ANCMHAL; -.
DR OrthoDB; 648032at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.30.310.10; TATA-Binding Protein; 1.
DR InterPro; IPR026739; AP_beta.
DR InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015151; B-adaptin_app_sub_C.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR11134; ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER; 1.
DR PANTHER; PTHR11134:SF4; AP-4 COMPLEX SUBUNIT BETA-1; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF09066; B2-adapt-app_C; 1.
DR PIRSF; PIRSF002291; AP_complex_beta; 1.
DR SMART; SM01020; B2-adapt-app_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF55711; Subdomain of clathrin and coatomer appendage domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002291};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR002291};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR002291}.
FT DOMAIN 718..835
FT /note="Beta-adaptin appendage C-terminal subdomain"
FT /evidence="ECO:0000259|SMART:SM01020"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 645..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 840 AA; 93215 MW; 2CE67101E446180B CRC64;
MAPPAQTHRS PSPSQPSGKG EVSDLKMQLR QLAGSRAPGT DDAKRELFKK VISCMTIGID
VSSVFSEMVM CSATSDIVLK KMCYLYVGNY AKNNPELALL TINFLQKDCK DEDPMIRGLA
LRSLCSLRVT NLVEYLVGPL GLGLKDSNSY VRTVAAIGVL KLYHISASTC MDADFLVTLK
HLMLNDRDAQ VVANCLCSLQ EIWGLEATKS EEASTERETL LSKPLIYYLL NRFKEFSEWA
QCAVLDLVSK YVPADNNEIF DMMNLLEDRL QHANGAVVLA TIKLFLQLTL SMADIHQQVY
ERIKAPLLTL VSSGGPEQSY AVLSHLHLLV MRAPYIFSAD YKHFYCQYNE PFYVKKLKLE
MLTAVANESN TYEIVTELCE YAANVDIPMA RESIRAVGKI ALQQYDVNAI VDRLLQFLEM
EKDHVTAETL VLVKDLLRKY PQWSHDCIAV VGNISSKNVQ EPKAKAALIW MLGEYAQDMQ
DAPYVLESLV ENWEEEHSAE VRLHLLTAVV KCFFRRPPET QKALGAALAA GVNDFHQDVH
DRALLYYRLL QYNVSVAERV VNPPKQAVSV FADTQSNEIK DRIFDEFNSL SVVYQKPSYM
FTDKEHRGPF AFSEEIGNLS IGAEPTDNVV PAQRIEANDK DLLLSTSDKE ESKGSSHNGS
AYSAPGYDGS LAAPSQTDLV SLDYKSTPSA ASTTSAIDDL LGLGLPAAAS SPPPPPVLKL
NTKAVLDPNT FQQKWRQLPI SISQETSISP QGVAAMTTPQ ALIRHMQGHS IHCIASGGQA
PNFKFFFYAQ KAEEPYTYLV ECIVNSSSCK VQLKIKADDQ STSQAFSELF QSALSKFGFS
//
