ID A0A1S4D456_TOBAC Unreviewed; 890 AA.
AC A0A1S4D456;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Disease resistance protein RGA3 {ECO:0000313|RefSeq:XP_016508225.1};
GN Name=LOC107825824 {ECO:0000313|RefSeq:XP_016508225.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016508225.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016508225.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR RefSeq; XP_016508225.1; XM_016652739.1.
DR AlphaFoldDB; A0A1S4D456; -.
DR PaxDb; 4097-A0A1S4D456; -.
DR GeneID; 107825824; -.
DR KEGG; nta:107825824; -.
DR OMA; CENANLM; -.
DR OrthoDB; 718527at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1248; OS08G0224000 PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051}.
FT DOMAIN 2..198
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 890 AA; 102086 MW; 6925293286893908 CRC64;
MVQEKFDKRL WVCVSDVFEV KVIAEKIVES AGGEKNNCLQ LDAVQKQLRE MLDGKKYLLV
LDDMWNEDAL KWSRLKNMVI GGAKGSKILV TTRSDVVAEV SGSIHQHKLG DLSEEDAWAL
FEKMAFECNK ESEHSSLVEI GKEIVKKCGG VPLAIRSVGS LLRLKRTEDE WIYFKNQDLS
SITRGGDSVM AILRLSYNHL PHHLKICFAY CSLFPKDFRI DRVDLIDMWI AQGFIQSTIS
NRDNLEDVAN SYFVDLLRRS FFQETKEYKS FPHFYKMHDL IHDLAKEVAD REFFSITKTE
DTEIVIPEQT LHASCLFQVG GSLEFPSPFY RKHMKLRTFI YLNGSKNVVI SNSTLERMVS
SFECLRILHL RRLEIKFLPQ SLGGLKHLRY LAISSRSIVT LPNSITKLHN LQILKLAQVL
KLVDCIKLKK LPRDIWRLVS LRRLVCLWCA SLTHIPPGLW QLASLIHLDF DGCKSLEDMP
PGISQLTSLR TLTSFIVGKE SCISGLASDK LNELKGLDLR NRLRIKFMGR ARAIGERIPA
DVVKRMKHLR YIWVEFERGN QEDDTGADLI MLEALQPHQN IERLRIENYS GSRFPSWLMV
DNLGFLLPKL VFLQIRDCHK CQKLPPLWQL PSLQNLVLLN LDVVESIDGL EGNDDKFMLR
SNTPTDERYF PSLKRLYLGI ISEKILKQIL CPPHHPSPLC NLNRLTLVSI EDLATMPEDV
FKSLTSLQYL SIYNCRNLVS LCRCLTHLTS LESLCIENCP LLDLSDEEAM QFEVPGNLST
FKAFYLGKLM SLPVWLQHFS GTLKSIEIWE CPNFTTIPEW IGDLIVLNWL EIYGSRMLTS
FPEGMRSLAA LQVLIVTRCS SSLKQRCEKE GGEDWPKIAH IPRVDIREGI
//
