ID A0A1S4D4L9_TOBAC Unreviewed; 404 AA.
AC A0A1S4D4L9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Rhomboid-like protein 15 isoform X2 {ECO:0000313|RefSeq:XP_016508219.1};
GN Name=LOC107825819 {ECO:0000313|RefSeq:XP_016508219.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016508219.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016508219.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase S54 family.
CC {ECO:0000256|ARBA:ARBA00009045}.
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DR RefSeq; XP_016508219.1; XM_016652733.1.
DR AlphaFoldDB; A0A1S4D4L9; -.
DR GeneID; 107825819; -.
DR OMA; QWWENIP; -.
DR OrthoDB; 23829at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR CDD; cd14287; UBA_At3g58460_like; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 1.20.1540.10; Rhomboid-like; 1.
DR InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR11009; DER1-LIKE PROTEIN, DERLIN; 1.
DR PANTHER; PTHR11009:SF25; RHOMBOID-LIKE PROTEIN 15; 1.
DR Pfam; PF01694; Rhomboid; 1.
DR Pfam; PF00627; UBA; 1.
DR SMART; SM01160; DUF1751; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF144091; Rhomboid-like; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 364..403
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 281..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 404 AA; 43437 MW; C74B9AE1CAE26D79 CRC64;
MRPNIVPEAG LQTRMGQWWE GIPVLTSAVV VVCGVIYLVC LLVGYDSFAE VCFWPSAVIS
RFQVYRIFTS ILFHGSLLHV LFNMLALVPL GSELERIMGS VRLLYIIALL AISSALFHLL
IALLVAHNPF HPSPYFMDEC AIGFSGILFS MIVIETSLSG AQTRSVFGLF NVPAKWYALI
LLVVFQLVMS NVSLLGHLCG ILSGFAYTYG LFNVLIPGTS FFSAIESSSY LSTCVRRPKF
IMSTGGNGAG YLPTHSIQTV TSSGVLSGNI WENLSSWMPQ RESSAQPVTD DSRFPGRGRT
LTSQTSTGNH DSTLQARLLS GSNSPERISA PTALGGERSL TGRQSAVDAT AGATRPIGQQ
GSIPSDESVQ KLVAMGFEKT QVEVALAAAE GDINVAVEIL SQQG
//
