ID A0A1S4D5P4_TOBAC Unreviewed; 1075 AA.
AC A0A1S4D5P4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Disease resistance protein TAO1-like {ECO:0000313|RefSeq:XP_016508750.1};
GN Name=LOC107826300 {ECO:0000313|RefSeq:XP_016508750.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016508750.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016508750.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016508750.1; XM_016653264.1.
DR AlphaFoldDB; A0A1S4D5P4; -.
DR STRING; 4097.A0A1S4D5P4; -.
DR PaxDb; 4097-A0A1S4D5P4; -.
DR GeneID; 107826300; -.
DR KEGG; nta:107826300; -.
DR OMA; HECEVTE; -.
DR OrthoDB; 1127757at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF589; DISEASE RESISTANCE PROTEIN TAO1-LIKE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051}.
FT DOMAIN 16..183
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1075 AA; 122146 MW; C1975392CD28F709 CRC64;
MDTQLVRGES STSSHFSYEV FLSFRGEDTR KTFTDHLYSK LRDVGVNTFI DEELRKGDVI
SRELEKAIEE SRISIIVFSR NYTSSSWCLN ELVKILECKE KLKQMVLPIF YDVDPSEVRK
QTGLFGEALA KHKERSIGAQ MVEKWRAALT EAANLSGWHL QNVADGHESK FIEKIIQQVL
QEVNQTPLDV AWHPVGVDSR VKDIELLLQN ECEDEVRMIG IHGVGGIGKT TLAKAIYNRM
FRLFDNSCFL SDVRSEAEEF GLVKLQKKLL RQILKTEDIK VGSVAQGINL IKARLGSKKV
LIVLDDMDHE RQLEALTRER SWFGSGSLII ITTRDERLLC QLREKERCEP KLLNENEAMS
LFCWHAFDNH FPPEDYIKLA HGIIEYSGRL PLALVILGSH FQGRSVEEWG HEFEKLRAIP
HCDIQKILKI SFDGLDDEIQ TVFLDIACAF HGFHECEVTE ILNACGFHAE SAIATLIQKH
LLQRDDLYLV MHDLVRDMGR EIVRMESARD PGKRSRLFIP QEVCDILQGN KGSENVEVLK
VDRETLKGVN LSTKAFEQMK NLRVLIMDEL HISGDLGLLS KKLRWLSWKK CPLKCIPSNF
PAENLVVLDM RESDIQEFGL NMQCCRSLKK LDLSRCKQLR STPNFSGSRS LETLLLRGCS
SLTEIHPSIG NLSSLIKLYM SDCEKLTDLP SSICQLISLE DLCIDDCSSV KTLPDNLGDM
KSLKSLSADY TGIKQLPRSV EMLTKLVTLR VGGQNLEAKR SISGRGVHRM QYSLSTFVSE
LSLTYCNLSE ADIPRDIGSL SSLKFLDLSG NSFHCLPFDF SKLRVLKKLC LNDSENLQTL
LSVSNLENLE ILELQNCQKL VKITELDNLP SIWSINMINC SSLQNPFNEG FFSAPALYVS
GKDPELERLE IYLECKEIPE WCRNQVTTSS ICLTMSMSTH NEEYNFLGMV LWFVTNCLDE
SFCPSFLISI AGRKTLISPW GIPDDGHREL SCLYYISYLN GAFDGQMIKG GEMVEVWAPD
FTVKKIGIDL LYVDQNGKVI SLPGDMDHSY SRAKDVRIRN WREELLSLAD TIKEI
//
