ID A0A1S4D6D0_TOBAC Unreviewed; 570 AA.
AC A0A1S4D6D0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Cationic amino acid transporter 2, vacuolar-like isoform X2 {ECO:0000313|RefSeq:XP_016508985.1};
GN Name=LOC107826511 {ECO:0000313|RefSeq:XP_016508985.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016508985.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016508985.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
CC {ECO:0000256|ARBA:ARBA00008572}.
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DR RefSeq; XP_016508985.1; XM_016653499.1.
DR AlphaFoldDB; A0A1S4D6D0; -.
DR GeneID; 107826511; -.
DR OMA; WQVDPEE; -.
DR OrthoDB; 1421713at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR029485; CAT_C.
DR PANTHER; PTHR43243; INNER MEMBRANE TRANSPORTER YGJI-RELATED; 1.
DR PANTHER; PTHR43243:SF4; LD37241P; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
DR PIRSF; PIRSF006060; AA_transporter; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 523..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 496..546
FT /note="Cationic amino acid transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13906"
SQ SEQUENCE 570 AA; 60002 MW; C307E1D2C25FF4C1 CRC64;
MGLVGGGEGG CFVGGVRSLI RRKQVDSAHS NPSSAAATSH NQLAKALTVP HLVAIGVGST
IGAGVYILVG TVAREHSGPA LTFSFLIAGI AAALSAFCYA ELASRCPSAG SAYHYSYICV
GEGVAWLIGW ALILEYTIGG SAVARGISPN LATLFGGPDS LPAFVARHTI PGLDVVVDPC
AAILVFVVTG LLCVGIKEST MVQGFVTTAN VCAMIFIIVA GGYLGFKTGW PGYELPVGYF
PYGVDGMLVG ASTVFFAFIG FDSVASTAEE VKNPQRDLPM GIGFALSICC SLYMLVSAVI
VGLVPYYAMD PDTPISSAFA SHGIKWAAYI ITVGACTALC STLMGSLLPQ PRILMAMARD
GLLPSFFSDV NKHTQVPVKS TVTTGLLAGT LAFFMDVEQL SGMVSVGTLL AFTMVAISVL
ILRYVPPDEV PLPSSFQAAI DSMGYQSRIH VWRKQQSDLA FSLTKGGKLL AGQSCSRVLE
CLCLHLLLQF VACQRFTCPF VPLLPIACIL INSYLLINIG GATWMRVSLW LALGVCVYAF
YGRTHSSLQN AVYVPATHVD EIYQSSASLA
//
