ID A0A1S4D9H0_TOBAC Unreviewed; 963 AA.
AC A0A1S4D9H0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Alpha-aminoadipic semialdehyde synthase-like isoform X2 {ECO:0000313|RefSeq:XP_016509864.1};
GN Name=LOC107827281 {ECO:0000313|RefSeq:XP_016509864.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016509864.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016509864.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016509864.1; XM_016654378.1.
DR AlphaFoldDB; A0A1S4D9H0; -.
DR GeneID; 107827281; -.
DR OrthoDB; 2184985at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006553; P:lysine metabolic process; IEA:UniProt.
DR CDD; cd12189; LKR_SDH_like; 1.
DR CDD; cd12144; SDH_N_domain; 1.
DR Gene3D; 1.10.1870.10; Domain 3, Saccharopine reductase; 1.
DR Gene3D; 3.30.70.2690; LOR/SDH bifunctional enzyme, conserved domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR007698; AlaDH/PNT_NAD(H)-bd.
DR InterPro; IPR007545; LOR/SDH_bifunc_enz_cons_dom.
DR InterPro; IPR043009; LOR/SDH_bifunc_enz_cons_dom_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032095; Sacchrp_dh-like_C.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR PANTHER; PTHR11133; SACCHAROPINE DEHYDROGENASE; 1.
DR PANTHER; PTHR11133:SF22; SACCHAROPINE DEHYDROGENASE [NADP(+), L-GLUTAMATE-FORMING]-RELATED; 1.
DR Pfam; PF04455; Saccharop_dh_N; 1.
DR Pfam; PF16653; Sacchrp_dh_C; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SMART; SM01002; AlaDh_PNT_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051}.
FT DOMAIN 99..297
FT /note="Alanine dehydrogenase/pyridine nucleotide
FT transhydrogenase NAD(H)-binding"
FT /evidence="ECO:0000259|SMART:SM01002"
SQ SEQUENCE 963 AA; 105511 MW; 953CFF03BCEB735F CRC64;
MILPDRAYAF FSHTHKAQKE NMPLLDMILA ERASLFDYEL IVGDTGKRLL AFGSFAGRAG
MIDFLRGLGL WYLNHGYSTP FLSLGSSYMY SSLAAAKAAV ISVGEEIATM GLPAGICPLV
FVFTGAGNVS RGAQEIFKLL PHTFVDPRKL SELHETARDL TQSKHPSKRI FQVYGCVTTC
QDMVERLNPS KSFDKIDYYA HPEQYGPAFH EKIAPYASVI VNCMYWEKRF PRLLTTKQIQ
DLMRNGCPLV GICDITCDVG GSIEFINQTS SIDSPFFRYE PSNDSYHFDI EGKGVMCSAV
DILPTEFAKE ASQHFGDILS HFTGSLASFR NLEELPAHLK RACIAHHGAL TQLYEYIPRM
RKSDLEDPST VLSSSNANGR KYTVLVSLSG HLFDKFLINE ALDIIEAAGG SFHLVKCQVG
QITSALSYSE LEVGAEDKAV LDKIVDSLTS LAYSRNSLGS QNKENNMISL KVGEFQQSIT
DEKSDAKVLI LGAGRVCRPA AELLASIGSM SSGQCLSSIT ADFEEQNCVQ VIVASLYLKD
AEEVTEGIPN AKAVQLDITN HESLSSCISQ VDVVISLLPP SCHGIVAKSC IELKKHLVTA
SYVNDSMLKL DEDAKCAGIT ILGEMGLDPG IDHMMAMKMI NQAHAANGKI RSFVSYCGGL
PSPAAANNPL AYKFSWNPAG AIRAGWNPAA YRSEGEIIHV EGQRLYDSAA KLRLPDFPAF
ALECLPNRNS LVYGDLYGVG EEASTIFRGT LRYEGFSQIM GTLAKIGFFC TEPSLILKDG
IKPTHRAFLL GLVGIDGQIF PEPVIDEKYI TDRILKLGLC KDKDTAVKTA KTIIFLGFQE
PTEIPSSCKS PFEVTCLRME ERLAYSNTEQ DMVLLHHEVV VDYPDGHAET HRSTLLEMGR
TANGKTNMAM SLTVGIPAAT GALLLLANKI KANGVLRPID PEVYEPALDI LEAYGFKLLE
KIE
//
