ID A0A1S4DC26_TOBAC Unreviewed; 1908 AA.
AC A0A1S4DC26;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC107828155 {ECO:0000313|RefSeq:XP_016510903.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016510903.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016510903.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_016510903.1; XM_016655417.1.
DR STRING; 4097.A0A1S4DC26; -.
DR PaxDb; 4097-A0A1S4DC26; -.
DR GeneID; 107828155; -.
DR KEGG; nta:107828155; -.
DR OMA; ECTMQHL; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0000077; P:DNA damage checkpoint signaling; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IBA:GO_Central.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_016510903.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 781..1465
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 1550..1860
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 1876..1908
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 742..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1838..1857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1327..1354
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1908 AA; 216566 MW; C966ECD81A0B601A CRC64;
MAKEVLAAGP QPRTILETII VTLAHLALHS EKIELEAVFM VCVIAAINPC LRKLVIVVLD
NLSRELKYTS RSKYMEELMA PILFSWVASG VNLAALLEVR DLFVFNVEPI NFIQSCCRWL
IPSLMLHGDI SNMNWLAKVT CEPLAEMIKN HFVDIFSVCI TLHSSKKAGW EKGSAVLEMS
ILDIAKISET ERDKLIKKHM VSIVNTIFSL ASTAVDPVLP SFSKETIARA IMTVVDGFLE
IDDSCQNFGL IDKINIFRPD RVFTFIVELH YKVAAAGHFR HKSDRLAGIE VLIDVLGHRV
AVPSTASYLL NLIGQCLDLD ALLDQCCRMI SSLLKIFKIK QLEGTTVVLG EQLQFLISKL
VMCCISSESS PKLSADTSSQ VLSLLSQLTL DSDPSLHEYI KELEPFPNID LFHDIRMFHE
ELCQNYSPRE HLSILGKRSR YLPPRLLVWS LKALHKKLFE DEAYPAQKNE ENIFEDAYLD
SDHEIVHTVW NLVHTCSLSG AGNFGSLVSD FLSRVGIGDP HGVVFHLPIE SKSVHEHNFH
LGTGISDDLL VAIMRLLKKY LMDDSVKIID IASQALRGIL STENGQRALL SFDSYQRSLI
EVHSKGVDVN LVQKLLADLE RKLNVEALSL KDSAIWKTDG KTFETWICPL ICALIEYCDD
MILRLCQDIV LVKSEVAELL FPYVMVNLSS RRDVDVDLCQ LISSQVQENI FTEDNKLTKS
IQVILDALNE LRLCHVMEIS TSSNPSKREN SKQYGRPSSY GSKSRSTPLK AKHQTTTSSV
VSISTLSWQK VYWISMDYLA VARSAILPRH IEILLSAVTQ INEPDSLYGI IQSHKLTSQI
ITFEHEGNWS KALEYYDLQI RSDPVAQGSS CTPENFLHSS GSAVDQMIEK KPYKGLIRSL
QQIGCTHLLX HYRNATQRPL FNPTMSLGVD VFGSKNTGSG SSGIMITSEP LMGSSNYLTW
ASSVELWCKG QGVQDHLTKK YEAAWRSGNW DFSLLYGESS VLSIQHGGDH FNENLHSCLR
ALKEGGFDEF QIKLKDSKQE LLLSICHASA ESTKYIYQAI VKLQILYHLG MTWDSRWTSS
CTMLDSMKMP KVSSKPVLPS ITQLSWLDMD WKRTLKQTQL HMNLLEPFVA FRRVLLHILN
CQDYTVQHLL ESAATLRKVA RFSQAASALH EFKFLCAEMG EHSNLYWLGR LEEAKLLRAQ
GQHQMAINLA KYISLNHQTN ENASDVFRLI GKWLAETRSS NSRTILEKYL KHAVVLAEDC
MARGKVSAIK RSQLHFHLAH YADALFRSYE ERLNSSEWQA AMRLRKHKTR ELEALVKRLR
SSTKGEKTDC SAKIQELQKQ LAMDKEEAEK LQEDRDNFLS TALDEYKRCL VIGDKYDVRV
VFRLISLWFG LSLRPIVVDS MLGTISEVQS YKFIPLVYQI ASRMGSTKES QGAQNFQFAL
VSLIKRMAID HPYHTIFQLL ALANGDRIKD KQRSRSSFVV DMDKKAAAEN LLKELSSYHG
AVIRQMKQMV EIYIKLAELE TKREDTNKKF NLPREIRSIR DLELFSCVLT IVFYSVMNGI
NAPKVVECFG SDGNKYRQLA KSGNDDLRQD AVMEQFFGLV NTFLQNRRDT WKRRLRIRTY
KVVPFTPSAG VLEWVNGTLP LGDYLIGSTR DGGAHGRYGA GDWTFMKCRQ HMTVESNKRK
AFQEVCDNFR PVMHHFFLER FFHPADWFQK RLAYTRSVAA SSMVGYIVGL GDRHSTNILV
DQATAEVVHI DLGVAFEQGL MLKTPERVPF RLSRDIIDGM GVTGVEGVFR RCCEETLSVM
RTNKEALLTI IEVFIHDPLY KWALSPLKAL QRQKESEDDL ETSLEDSQQD DYEGNKDAAR
ALMRVKQKLD GYEEGEMRSV HGQVQQLIHD AIDPDRLCHM FPGWGAWL
//
