ID A0A1S4DL12_TOBAC Unreviewed; 929 AA.
AC A0A1S4DL12;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Disease resistance protein RGA3 {ECO:0000313|RefSeq:XP_016514076.1};
GN Name=LOC107830907 {ECO:0000313|RefSeq:XP_016514076.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016514076.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016514076.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR RefSeq; XP_016514076.1; XM_016658590.1.
DR AlphaFoldDB; A0A1S4DL12; -.
DR SMR; A0A1S4DL12; -.
DR PaxDb; 4097-A0A1S4DL12; -.
DR GeneID; 107830907; -.
DR KEGG; nta:107830907; -.
DR OMA; FSYCSEW; -.
DR OrthoDB; 1122392at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155:SF1156; DISEASE RESISTANCE PROTEIN RGA3; 1.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051}.
FT DOMAIN 6..98
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 188..407
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 929 AA; 106300 MW; 88705969B45F7F05 CRC64;
MAEVLVSIVL DQLGNFIVEQ VKGQVDELRM AIGIKKEIQN LSFKLKMIKE ALDDAEKRRV
KDKNVKHWLE ILEDFSYDTD NVLDEWKTRI LQQEIERNEA GVGAASIPRK KVSCFFLPSC
FTFKKLEVNR DIVRKIKELD VKLEVIVREK DQFNFVVNAN GVVSDQDVFK RVMTTGIVDE
SEVHGRDSDK DVVISKLLEN YDQENGFLVV SVVGTGGIGK TTLAQLAYGD EKIKGHFDER
IWICVSDPFD EVKVAKAILE SLTKSSPDLS QLHMLLERIQ ECVSKKRFFL VLDDVWSEDY
SKWEPLKNSL KNGARGSRIL VTSRSERVVG VMGSSYMHRL GQISDSDCWS LFSRIAFSGR
NKEDFENLED IGKRIVRKCK GLPLAAKTMG SLLRFKDTEE EWQTVLDSEI WELEEVAVDL
FPHLYLSYDD LPPILKRCFS YCAIFPKDTV INVDRLTRIW MAQGYLSTVE NNQQEVKGRE
YFMNLATRSF FHELKKDDKN ASVIISCKMH DIVHDFAQFL SKNDCYSIKG TKATENKVDV
LSVRHLCWES TDSTVNPTSI CDIGKIHSLF AEHLHAKELP RDLFKGLKCI RVLNLHGCLM
QELPEEIGNL FHLRCIDLSS SQVKDLPEAI CRLCNLQTLD LHGCKNLSRL PQQIGKLLNL
RHLITTDMPK LESFPQGIGR LTQLRTLSDF VVGKGSSKLG YIGKLNQLQG YLSVHVIDNL
NSAEDVVEAE KAEFRSKKYV KELRLNFYWT SEVRMDVIEA LTPPPNLRSL TINGYRGTQL
PTWITLSLNN LRVLTLSECF NCNFLPPLGK LPFLEILWVR LMDELKHVGN EFLGLPGTIA
SFPKLKKLTF SYCSEWEEWT DLKPEVVCSV MPSLKELELY CCEKLNSLPY CLLQRLSSIE
SLKIKMCPYL EVDWTKISHI QNIETGNGI
//
