ID A0A1S4DNE0_TOBAC Unreviewed; 1249 AA.
AC A0A1S4DNE0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Disease resistance protein RGA1 {ECO:0000313|RefSeq:XP_016514942.1};
GN Name=LOC107831671 {ECO:0000313|RefSeq:XP_016514942.1};
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000084051, ECO:0000313|RefSeq:XP_016514942.1};
RN [1] {ECO:0000313|Proteomes:UP000084051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TN90 {ECO:0000313|Proteomes:UP000084051};
RX PubMed=24807620; DOI=10.1038/ncomms4833;
RA Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA Goepfert S., Peitsch M.C., Ivanov N.V.;
RT "The tobacco genome sequence and its comparison with those of tomato and
RT potato.";
RL Nat. Commun. 5:3833-3833(2014).
RN [2] {ECO:0000313|RefSeq:XP_016514942.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR RefSeq; XP_016514942.1; XM_016659456.1.
DR AlphaFoldDB; A0A1S4DNE0; -.
DR SMR; A0A1S4DNE0; -.
DR STRING; 4097.A0A1S4DNE0; -.
DR PaxDb; 4097-A0A1S4DNE0; -.
DR GeneID; 107831671; -.
DR KEGG; nta:107831671; -.
DR OMA; WILARDI; -.
DR OrthoDB; 1025058at2759; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039203; RGA2/3-like.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR36766:SF53; DISEASE RESISTANCE PROTEIN RGA2-LIKE; 1.
DR PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000084051}.
FT DOMAIN 10..92
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 168..410
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1249 AA; 143278 MW; D7160766B795B4CA CRC64;
MADPVIGATV QVLLEKLLSL TSEEVKSLRN CKKDLKMLKK TLTMIQAFIH DAERRQVEDQ
TVEEWLKMLE KVAEDAENVF DEFRYESLKA EVMKIQNKPM KKVRNFVSNT VLKWKMSRKI
NNISDELSAI NKLAKDLGLQ PPRGPSRQIL PVRETDSVVV ASDVVGRDKD VSEIKEKMLN
MREDVVLCTI PIVGMGGSGK TTVAKIIFND EQIKQHFEKR VWLCLPEMLE TKSFLELMLE
SLTERKLEVQ SRDIIVKKLQ DELGGKRYLL VLDDLWRVDP TILWHDFLDT LKGINTFRGN
CILVTTRRDQ VASSVAADPH TLKKLTDDHC WSIFKQRAFV DGEVTEELVS MGNRIVEMCK
GLPLAASVLG GLLRNKEKHE WQTILEGNPL VAGEDDSGQS SLKKILKLSY FYLPSPHLKK
CFAYFAMFPK DFEFEKDQLI QLWMAEGFLR PCQKTTVMED VGNKFFELLL ENSLLQDVKL
DEHNNITHCK MHDLVHDLAE DILKSKLFDG GDNLSQVRYF GWNSPRDQIE KINEPGRLCT
LFWKSSDMSE DMLLSFQFLR VLNLSQSGIK ELSASIGKLI YLRYLDLSRT SIDALPNSIC
KLYNLQTLRV NNCNILNGFP DEMEHMISLR HIYYNSYRFQ ILNMGKLTCL QTLQHFKVGL
EKGRGIEELG HLKNLRGELT INGLQLVRNR EEAGRAYLKE KPNIYKLAYF WSNRGCEIND
EYVLDGLQPH PNLKTLEVVD YLGTRFPSWF NGEFLPNLVK LKLIGCRKCI EIPSLGQLKL
LRHLELVGFD KMECIGPAFY GVDVNYNGSS SNNANIQVFP LLKELVLKHM PSLIEWKGVE
LMPTRDGGRD RVVVRMFPAL EKLSISNCRR LKSTPNQFEV LRELSIEVVD SEMPLLTLCS
NLTSLVELTV YDVKELTCLP DEMLRNNISL QHLSVLKCGE FRELPQSMYN LQSLKSLKIR
FCNISSVPVP SGENHLTSLR SLDFYSCDRL TSLPSEMLEH CRSLEFLSVS CCNNLVSLPL
HEWEMPSLSY LDISECPKMN SIPAGGLHRL TGLRELTIGL FSELVDFEAF QLMFNGIQQL
SSLRTFWVYG RANWDSLPYQ FMQLSALTRM VIFNFGIESL PQNLDNLISL ESLELWSSER
LQRVDFSGVM PKLRRLEIHN CPLLEALSGR VVNLVSLEAL YLSNCKKLQH LPSGDDMRRL
TKLRCLRIEA CPQLEESCTN RSGPNSQWSN ISHIPEIYIR GRTIPILRD
//
