ID A0A1S4DS83_CUCME Unreviewed; 1130 AA.
AC A0A1S4DS83;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA repair protein REV1 {ECO:0000256|ARBA:ARBA00020399, ECO:0000256|PIRNR:PIRNR036573};
DE EC=2.7.7.- {ECO:0000256|PIRNR:PIRNR036573};
GN Name=LOC103482574 {ECO:0000313|RefSeq:XP_016898828.1};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_016898828.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|RefSeq:XP_016898828.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Deoxycytidyl transferase involved in DNA repair. Transfers a
CC dCMP residue from dCTP to the 3'-end of a DNA primer in a template-
CC dependent reaction. May assist in the first step in the bypass of
CC abasic lesions by the insertion of a nucleotide opposite the lesion.
CC Required for normal induction of mutations by physical and chemical
CC agents. {ECO:0000256|PIRNR:PIRNR036573}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR036573}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945, ECO:0000256|PIRNR:PIRNR036573}.
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DR RefSeq; XP_016898828.1; XM_017043339.1.
DR AlphaFoldDB; A0A1S4DS83; -.
DR OrthoDB; 169741at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0042276; P:error-prone translesion synthesis; IEA:InterPro.
DR CDD; cd17719; BRCT_Rev1; 1.
DR CDD; cd01701; PolY_Rev1; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 6.10.250.1490; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 2.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR024728; PolY_HhH_motif.
DR InterPro; IPR012112; REV1.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR45990; DNA REPAIR PROTEIN REV1; 1.
DR PANTHER; PTHR45990:SF1; DNA REPAIR PROTEIN REV1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF11798; IMS_HHH; 1.
DR PIRSF; PIRSF036573; REV1; 2.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|PIRNR:PIRNR036573};
KW DNA repair {ECO:0000256|PIRNR:PIRNR036573};
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634,
KW ECO:0000256|PIRNR:PIRNR036573};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR036573};
KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR036573};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036573};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW Transferase {ECO:0000256|PIRNR:PIRNR036573}.
FT DOMAIN 93..184
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 435..616
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1130 AA; 125183 MW; F0F6B9E639E25B19 CRC64;
MNSDSSRSAN SSAQRSKRIL DNSSPSNPSG TGGNKKKRIN QKTLGVAWGA NSISSSRKSP
FSDFGSYMVE KNRKLHNQFN FDASSASHSG VNSGNQIFQG VSIFVDGFTI PSSQELRGYM
LKYGGRFENY FSRRSVSHII CSNLPDSKIK NLRSFSRGLP VVKPTWILDS VASNKLLSWV
PYQLDQLVSN QPRLSEFFSM KKGPTVEKPK ICMTSEKKYE TEDSLSSVAM NLKDTTVLEV
NESIGYRAEM HSDSVMNLQV NADAEMNEKS SDDLEAAKLK DTSISDVDVS IEYKPHFCES
FEMLPQKDAD VEVHKGPSNE KYNYVDEEPG IVDVGQSSEE NISSFHGLSA STHNGSSNSY
HSDGSSSSMA AGSSKLQHST LENPDFVENY FKKSRLHFIG TWRNRYYKRF PRLANGSNSV
TSHINGSSHH QSATIIHVDM DCFFVSVVIR NIPKFKDRPV AVCHSDNPKG TAEISSANYP
ARSYGVRAGM FVRDAKALCP HLVIFPYDFK SYEGVADQFY EILHKHCEKV QAVSCDEAFL
DISGTNNVDP EVLASKIRKE IFDTTGCTAS AGISTNMLMA RLATKTAKPD GQCYIPLEKV
DDYLNPLPIK DLPGIGHALE EKLKKRSILT CSQLRMISKD SLQKDFGLKT GEMLWNYSRG
VDNRAVGLIQ ESKSIGAEVN WGVRFKDFKD CQCFLLNLCK EVSLRLNGCG VQGRTFTLKV
PVATDDLEIL QRIVKQLFGF FVIDVKEIRG IGLQVSKLQN VDISRQGTKR NSLDSWLSSS
ATTNVENVIG PSVKEVANID NEKQSNSGTL DQLSTDPISH PIQMENNQHH SEALNPVSPP
PLCNLDIGVI RSLPPELFSE LNEIYGGKLI DLLAKSRDKN EVFSSSIRVL SQGSQGDGLT
LSDIQGNKVQ SENKISGEGL CNLVAPLTTS GSHRIDLLPS SLSQVDPSVL QELPEPLRDD
ILKQLPAHRG KELSLEHAVK NHRESGSAVE NTSGSLDPLM ENDLWSGNPP LWVDKFKASN
CLILELFAEI YTESGLPGNL YGILLRTLSQ SWHPSAADSD GWDGAIYGLC ELLKQYFKLK
IELDIEETYV CFRLLKRLAM KSQLFLEVFN IIDPYLQGAV NEIYGGSLKV
//
