ID A0A1S4DSI2_CUCME Unreviewed; 1110 AA.
AC A0A1S4DSI2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=LOC103484188 {ECO:0000313|RefSeq:XP_016898957.1};
GN Synonyms=103484188 {ECO:0000313|EnsemblPlants:MELO3C006599.2.1};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_016898957.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|EnsemblPlants:MELO3C006599.2.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2023) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_016898957.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016898957.1; XM_017043468.1.
DR EnsemblPlants; MELO3C006599.2.1; MELO3C006599.2.1; MELO3C006599.2.
DR Gramene; MELO3C006599.2.1; MELO3C006599.2.1; MELO3C006599.2.
DR eggNOG; KOG0331; Eukaryota.
DR InParanoid; A0A1S4DSI2; -.
DR OrthoDB; 313533at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR Proteomes; UP000596662; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1.
DR PANTHER; PTHR47958:SF176; DEAD-BOX ATP-DEPENDENT RNA HELICASE 40; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_016898957.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565}.
FT DOMAIN 20..54
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 503..653
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 682..826
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..1110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..971
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..997
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1024
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1047
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1110 AA; 121569 MW; 8BCB1B5EEC131E95 CRC64;
METGDSAPPS LGPRYAPDDP TLPKPWKGLI DGSTGLSYYW NPETNVTQYE KPVSLPPPLP
LGPHPGVSIS KPTSIPEAHS MPSSGTVAPH VQQNHYNIPQ QDGQLNNQLS QQPGHLISQQ
HSSVASQVAV NHHPGMQMAP DGRQHGSQPN QVMQQQGVFG MSSQHIGQQQ VMHQGQNMAH
ANQQMSQHPN QQPLQNPGQA LQNPGQQMPQ PSVQHLGQPN MQNPKPLVGQ PQGPQYGQQQ
LQYIGYQQSL HPNVQQNSQQ QVQQSPLVQP FGNHLEQKPA FLKRDEENIQ SGNQVGFPSS
QFQQSGGTPS IHNIHSGTNS SQMQQLGTFG SSPGNMQQQL PVGQVQHAST ELTHRHHHSR
FQDQMGPAVM QGQQPVAENL PGRGGNEYYF GRNEGSGIGP HQPRLAAIPM ARSQQDSRMS
GDPFPNSAPV HPSGTKFAGG PTHNLYSHGS GVPSLPNNAL MGPPHVGVSD VNMSPVEVYR
RQHEVTATVC ISACLSFPIM LELLPAFILL RQCRNNPQNG PTVLVLAPTR ELATQIQDEA
IKFGRSSRVC CTCLYGGAPK GPQLKELDRG ADIVVATPGR LNDILEMKMI NFRQISLLVL
DEADRMLDMG FEPQIRKIVN EIPPRRQTLM YTATWPKEVR KIANDLLVNS VQVNIGSVDE
LAANKAITQY VEVVPQMEKQ RRLEQILRSQ ERGSKVIIFC STKRLCDQLA RNLGRGFGAA
AIHGDKSQGE RDWVLNQFRS GKSPILVATD VAARGLDIKD IRVVINYDFP TGIEDYVHRI
GRTGRAGATG VAYTFFSEQD WKFSSDLIKV LEGAGQPVPP ELRNMAMRGG PGFGKDRGGM
GRYDAVMGGS RWDSGGRGGM SDAGFGGRSG ARDGGFGGHG GMRDGGFGGR GGMRDGPGGR
GGRGDFFSTR GRGRGFGGPM GGHVGWGRGD RGGPHDRFNG VDGRGRGRGQ GRFDNRRDFS
NRSRGRSYSR SPERVRTWGY SRSRSRSRSG SRSRSSRSWS RSRSRSHSRS RSRSRSWSRR
YSRSRSRSRS QDNNERPRVR NFDKKDNPPL ESVGAASPDT QKNRFEEQED ARQLAPMPGS
NNMEAMNPEN GDTIDQTVNA GAQSNMNESE
//
