ID A0A1S4DTW1_CUCME Unreviewed; 501 AA.
AC A0A1S4DTW1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Histone-lysine N-methyltransferase ASHH1 isoform X2 {ECO:0000313|RefSeq:XP_016899437.1};
GN Name=LOC103485603 {ECO:0000313|RefSeq:XP_016899437.1};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_016899437.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|RefSeq:XP_016899437.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_016899437.1; XM_017043948.1.
DR AlphaFoldDB; A0A1S4DTW1; -.
DR GeneID; 103485603; -.
DR OrthoDB; 54704at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR22884:SF455; HISTONE-LYSINE N-METHYLTRANSFERASE ASHH1; 1.
DR PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 34..85
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 87..204
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 211..227
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT COILED 385..426
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 501 AA; 56828 MW; 45B78EE51179760A CRC64;
MKLVAEFYEH FLMEILKKLE LPCLVLRHKK QKEEDIAVCE CKFDANDNDS ACGEGCLNVL
TSTECTPGHC PSGVHCRNQR FQKCEYAKTK LFKTEGRGWG LLADENIKNG QFIIEYCGEV
ISWKEAKRRS HTYENQGLKD AYIISLNASE SIDATRKGSL ARFINHSCFP NCETRKWNVL
GEIRVGIFAK QDISIGTELA YDYNFEWYGG AKVRCLCGAS SCSGFLGAKS RGFLEDTYLW
EDDDDRYSVE KIPLYDSAED EPSVMLHTAL NNTYSEFEGY LKNEDPIIVD DDLGAEQQLG
STAFIDTSKD IVQLQNIVVG EIKNEAKEEP EDHPQNTQQN FSHQNAMISR IRSNTACHNY
RIGPRPVAKK RSRNLSNGRT KNFSLKQVDA KYVAQLLEMK EAQDEVLQYE ETKKKVTAEL
DSLYNEIRPA IEEYERDSQD SVATSVAEKW IEASCLKLKA EFDLYSSIVR NVACTPLRSC
VSTEPQALEA DVDNDLKLLT N
//
