ID A0A1S4DYC8_CUCME Unreviewed; 586 AA.
AC A0A1S4DYC8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Alpha-aminoadipic semialdehyde synthase isoform X3 {ECO:0000313|RefSeq:XP_016900978.1};
GN Name=LOC103492407 {ECO:0000313|RefSeq:XP_016900978.1};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_016900978.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|RefSeq:XP_016900978.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_016900978.1; XM_017045489.1.
DR AlphaFoldDB; A0A1S4DYC8; -.
DR OrthoDB; 2184985at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006553; P:lysine metabolic process; IEA:UniProt.
DR CDD; cd12144; SDH_N_domain; 1.
DR Gene3D; 1.10.1870.10; Domain 3, Saccharopine reductase; 1.
DR Gene3D; 3.30.70.2690; LOR/SDH bifunctional enzyme, conserved domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR007545; LOR/SDH_bifunc_enz_cons_dom.
DR InterPro; IPR043009; LOR/SDH_bifunc_enz_cons_dom_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032095; Sacchrp_dh-like_C.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR PANTHER; PTHR11133; SACCHAROPINE DEHYDROGENASE; 1.
DR PANTHER; PTHR11133:SF22; SACCHAROPINE DEHYDROGENASE [NADP(+), L-GLUTAMATE-FORMING]-RELATED; 1.
DR Pfam; PF04455; Saccharop_dh_N; 1.
DR Pfam; PF16653; Sacchrp_dh_C; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 531..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..75
FT /note="LOR/SDH bifunctional enzyme conserved"
FT /evidence="ECO:0000259|Pfam:PF04455"
FT DOMAIN 150..245
FT /note="Saccharopine dehydrogenase NADP binding"
FT /evidence="ECO:0000259|Pfam:PF03435"
FT DOMAIN 249..577
FT /note="Saccharopine dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16653"
SQ SEQUENCE 586 AA; 64377 MW; 4A93A198598EEA38 CRC64;
MFNIQVSLSG HLFDQFLINE ALDIIEAAGG SFHLVHCQVG QNANAMSHSD LEIGADDIGI
LDKIIHSLSR MANPQENLDL VNNETNKIFL KVGKIQESGF KSEDVKRKTA VLLLGAGRVC
YPAVDLLASS GNSCCQFWKT FLEQYAEDWN DIEVIVASLY LKDAKEITED IANATAVELD
ITDSEKLFMY ISQVEVVISL LPPSCHLTVA NACIELRKHL VTASYINDAM TLLDEKARNA
GITILGEMGL DPGIDHMLAM KMINESHLQN RIVKSFMSYC GGIPSPESAN NPLAYKFSWN
PAGAIRAGSN PATYKYEGKT VKVEGKDLYD SAVRLRLPDL PAFALECIPN RNSLIYGDVY
GIGHEASTIF RGTLRYEGFS EVMGTLARIG FLDAEVHSFL RNGRPLFRDF LLELLKIKGV
SSGSTIGEKA ISESLISSGL CKVQETAVKV AKTIVFLGLH EPTEIPSSCQ SAFDVTCYRM
EERLTYSKNE QDMVLLHHEI QVATPDDQQT ECRKATLLEF GTTMNGKSTS AMALTVGIPA
AIGALLLLTN KIKTRGVLRP IESEVYIPAL DLLQAYGFKL TEKVES
//
