ID A0A1S4E2G9_CUCME Unreviewed; 1268 AA.
AC A0A1S4E2G9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=TMV resistance protein N-like {ECO:0000313|RefSeq:XP_016902418.1};
GN Name=LOC103498647 {ECO:0000313|RefSeq:XP_016902418.1};
GN Synonyms=103498647 {ECO:0000313|EnsemblPlants:MELO3C022145.2.1};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_016902418.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|EnsemblPlants:MELO3C022145.2.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2023) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_016902418.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016902418.1; XM_017046929.1.
DR EnsemblPlants; MELO3C022145.2.1; MELO3C022145.2.1; MELO3C022145.2.
DR Gramene; MELO3C022145.2.1; MELO3C022145.2.1; MELO3C022145.2.
DR eggNOG; ENOG502R41B; Eukaryota.
DR InParanoid; A0A1S4E2G9; -.
DR OrthoDB; 1103758at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR Proteomes; UP000596662; Unplaced.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF585; AAA+ ATPASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 2.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565}.
FT DOMAIN 12..152
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1268 AA; 144162 MW; E189BFA735422C5A CRC64;
MAAGSSSHPS QMAFDAFLSF NRDEEDDGYR YFIKGLYETL SEWGIKLFMD DGKKMFTDDE
VNLSDNIVKA IEGSITSIVV LSKGYATSKW CLRELVKIIV QKDKTKHQVL PLFYGEKYAI
RPAIFSFGRY GPSPLIDVRK IDGYSKKSSR EAKCKAAPEN FIYSEAEIDL MNDHKSRLAL
SEVFRLPGVD IPRFPGVDVP RFPGVDMQPK FLYTNIQIKS IAKQIIDHLL SLKLEAKEGT
LFEMPPRLRT MEMLFGLGSN DIRVIGIVGM RGIGKTTLAE HIFNHYFKYF SVGKYCFLHI
VGRSIVSLQQ QLLDQLGCSN FFSYQLWDED LLVIFMMECL SSLKNVLIVF DGISEISQLK
MLAGSPDWFG EGSRIIITTT NKEIFRHPNF KDKVQEYNVE LLSHEAAFSL FCKLAFGDHP
PSEDMKDLCN EIIEKVGRLP LALEKIAFSL YGHDMDIWED TLKNFHKVVY DNIFSDILKS
SYEGLEAESQ QIFLDLACFL NGEKVDRVIE ILQGFGYSSP QTNLQMLVDR CLIDILDGHI
QMHILILCMG QEIVRRKMGN CQQTRIWLRD DARRIFHENN ELKYICGIVM DLEEEEELIL
KAKVFADMSE LKILRINNVQ LSEDIEFLSN KLTLLNWPGY PSKYLPSTFQ PPSLLELHLP
GSNVERLWNG TQKFKNLKEI DASDSKYLVE TPNFSEARNL RRLILRNCGR LKEVHSSINS
LHRLILFDVE GCVSFKSFSF VITCESLKTL VLSNCGLEFF PEFGFPMGYL TELHIDGTSI
NELSPSIKNL LGLVLLNLGN CIRLSSLPTE IGSLSSLKTL ILNGCKNLHK LPPSLEYVKP
LEELDIGGTS ISTIPFVENL RILNCERLKS IIWHSLASLP TEYFSSLKDL NLSDCNLVDE
DIPSDLELFS SLEILDLGSN HFERLSESIE QLINLKVLYL NDCHKLKQLP KLPQSIRYVG
GEKSLGMLTT SQGSPACTMS PSSSNAPLLT NNDNFQNTKE VDIIKDMGKR TDHKLVLSHK
TSLVGMENQV EKVCNLLDLE RSKEILFVGI FGSSGIGKTT IAEVVYNTIV DQFRSGCFLY
LSSKQNSLVP LQHQMLSHLL SKETKIWDED HGAQLIKHHM SNRKVLIVLD GVDERNQIEK
LVGSPNWFAP GSRVIITARN RDVLHQLDYR DQVQEYKVEL LSPESAYSLF CKNAFGDGPY
DKNDLCSEIV EKVGRLPLAL RTIGSYLHNK ELEVWNETLK RLDEVEQNFF DTISQRTQKK
TTPTLGQI
//
