ID A0A1S4E3G6_CUCME Unreviewed; 544 AA.
AC A0A1S4E3G6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Nuclear envelope integral membrane protein 1 isoform X1 {ECO:0000313|RefSeq:XP_016902769.1};
GN Name=LOC103500299 {ECO:0000313|RefSeq:XP_016902769.1};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_016902769.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|RefSeq:XP_016902769.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000256|ARBA:ARBA00004575}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004575}; Nucleoplasmic side
CC {ECO:0000256|ARBA:ARBA00004575}.
CC -!- SIMILARITY: Belongs to the NEMP family.
CC {ECO:0000256|ARBA:ARBA00005748}.
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DR RefSeq; XP_016902769.1; XM_017047280.1.
DR AlphaFoldDB; A0A1S4E3G6; -.
DR GeneID; 103500299; -.
DR KEGG; cmo:103500299; -.
DR eggNOG; ENOG502QSQQ; Eukaryota.
DR InParanoid; A0A1S4E3G6; -.
DR OrthoDB; 472321at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR019358; NEMP_fam.
DR PANTHER; PTHR31587; TRANSMEMBRANE PROTEIN (DUF2215); 1.
DR PANTHER; PTHR31587:SF4; TRANSMEMBRANE PROTEIN (DUF2215); 1.
DR Pfam; PF10225; NEMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 68..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 544 AA; 61871 MW; 185F481AAA0DD953 CRC64;
MPLKVVDATL SDFNAVFDKF RSQLPNNKAN FILFLADKDP STSRSWCPEK GSFSSILRTR
KSMVHSKLFR ASTCLLFLSV FFASVYCTSD PEDHRLIVSE STTIQLSGGL PVKNSPGSKP
GTVVACERVY IQGLPRFKNL KKAAHTVKVK VSSRNSSFWM SNVEVCFHRN MSLGIGMCPQ
SQWEKVGRGS WVQSMSPFDH KLLDIRTCGL SLESFEVSTE DEFFLYRIIF LILGVLLMSS
ASILSKSLVF YYGSGMAIGI LLIVLMILFQ GMKLLPTGRK SSLVIFLYAS AVGLGSFFIR
YIPGLLYQIL MEMGISEDMY NPLAAFLLAF IFLIGAWLGF WVVHKFVLDE DGSIDTSTSL
FVTWSIRILA SLLILQCSLD PLLATGVLIC GIVASSMLRK IFKFRFLRRL FKNLFKSPKK
IPKRSHISDM PRWDDSDDEC TLKTTPLYKE PRFYRSQNRK FLLQSCDSSK HGDVYPSTFH
STPERRKFSK DEWEKFTKDS TKKALEGLVS SPDFSSWLVD RADRISITPQ SSRAEKRRKW
LHWF
//
