ID A0A1S6EQA8_9CAUL Unreviewed; 320 AA.
AC A0A1S6EQA8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=thymidylate synthase {ECO:0000256|ARBA:ARBA00011947};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN ORFNames=BZG35_00280 {ECO:0000313|EMBL:AQR60265.1};
OS Brevundimonas sp. LM2.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Brevundimonas.
OX NCBI_TaxID=1938605 {ECO:0000313|EMBL:AQR60265.1, ECO:0000313|Proteomes:UP000189107};
RN [1] {ECO:0000313|EMBL:AQR60265.1, ECO:0000313|Proteomes:UP000189107}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LM2 {ECO:0000313|EMBL:AQR60265.1,
RC ECO:0000313|Proteomes:UP000189107};
RA Hentchel K., Vargas G., Fiebig A., Chen S.L., Coleman M., Crosson S.;
RT "Genome sequences of bacteria isolated from the littoral zone of southern
RT Lake Michigan.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP019508; AQR60265.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1S6EQA8; -.
DR STRING; 1938605.BZG35_00280; -.
DR KEGG; brl:BZG35_00280; -.
DR OrthoDB; 7182974at2; -.
DR Proteomes; UP000189107; Chromosome.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR PANTHER; PTHR11548:SF9; THYMIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 62..237
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
SQ SEQUENCE 320 AA; 36390 MW; 8C99323280716851 CRC64;
MECSGDSLDD VLIQLYNALG KTTRRNEEGS RGSNFEILGV SLHVSNPRAR LSRSENRGKT
FSALGELLWY LSGREDLGFI EPYVPIYRDE VVNGIIEGAY GPRLFDMRGI NQIDSIISIL
SRKPGTRRAV IQLFNAEDIA IDKKEIPCTT TLQFHLREDG LHLSVTMRSN DAYWGLPHDV
FCFTMMQELI ARRLNVELGT YMHYAGSMHV YDNFYDDMKS YVSEGYQRPA PMPEMPIGDN
FALVPAILAA EDSIRHGEPI GAALQSNAYW KDIIILVEAY WASGQPEKLD KLKEQLHEPM
YFPYIDARKT MAVRAPLKRQ
//
