ID   A0A1S6FPC7_9SPHN        Unreviewed;       497 AA.
AC   A0A1S6FPC7;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:AQR75320.1};
GN   ORFNames=BXU08_18105 {ECO:0000313|EMBL:AQR75320.1};
OS   Sphingomonas sp. LM7.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingomonas.
OX   NCBI_TaxID=1938607 {ECO:0000313|EMBL:AQR75320.1, ECO:0000313|Proteomes:UP000189383};
RN   [1] {ECO:0000313|EMBL:AQR75320.1, ECO:0000313|Proteomes:UP000189383}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LM7 {ECO:0000313|EMBL:AQR75320.1,
RC   ECO:0000313|Proteomes:UP000189383};
RA   Hentchel K., Vargas G., Fiebig A., Chen S.L., Coleman M., Crosson S.;
RT   "Genome sequences of bacteria isolated from the littoral zone of southern
RT   Lake Michigan.";
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP019511; AQR75320.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1S6FPC7; -.
DR   STRING; 1938607.BXU08_18105; -.
DR   KEGG; splm:BXU08_18105; -.
DR   Proteomes; UP000189383; Chromosome.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006905; Flavin_halogenase.
DR   InterPro; IPR033856; Trp_halogen.
DR   PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR   PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR   Pfam; PF04820; Trp_halogenase; 1.
DR   PIRSF; PIRSF011396; Trp_halogenase; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   4: Predicted;
KW   FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW   Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189383}.
FT   ACT_SITE        78
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT   BINDING         13..16
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         78
FT                   /ligand="7-chloro-L-tryptophan"
FT                   /ligand_id="ChEBI:CHEBI:58713"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         334
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         343
FT                   /ligand="L-tryptophan"
FT                   /ligand_id="ChEBI:CHEBI:57912"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         347
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ   SEQUENCE   497 AA;  54726 MW;  0015049CD43F2CA9 CRC64;
     MTQPRKNVVV VGGGTAGWMV ASAIAKLLPH AASVELIESA EIGIVGVGEA TLPHLRAFIQ
     TLGLDEAEFM AATHATYKLG IEFRDFGKPG DVYLHPFGVF GQPLNGVPFL HWWLRMHAQG
     RGGEIAEYSV ANVMAVQQRF AVPAADPTTL LSTYGYAYQF DATKFGPFLR GFAEKRGVTR
     TEGRIVTVDR DGESGDVAAV VLESGARVEG DLFVDCSGFR SLLLGDALGE EWEDWSHWLP
     CDRATALPCA SPRGEIEPVT RATAMAAGWR WRIPLQHRVG NGYVYSSAHL SDDAASDAIL
     AAVDGEPLAE PRMLRFRAGR RKRSWSHNVV AIGLASGFLE PLESTSIYLA QAAITQLLDL
     FPIGPIEDAD RDAFNTQIDY EYDRIRDFLI LHYHASTRDD SEFWRYVRHM PIPDSLAEKI
     ELFRRAGRIQ RYSRGLFFEP SWIAVMIGQG IIPQAWDQRV DAANPGELGQ ALDRLRGQIA
     REVATLPGHR AALGLSA
//