ID A0A1S6QHR1_9LACO Unreviewed; 636 AA.
AC A0A1S6QHR1;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=PTS sugar transporter subunit IIA {ECO:0000313|EMBL:AQW21129.1};
GN ORFNames=PL11_003915 {ECO:0000313|EMBL:AQW21129.1};
OS Lentilactobacillus curieae.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lentilactobacillus.
OX NCBI_TaxID=1138822 {ECO:0000313|EMBL:AQW21129.1, ECO:0000313|Proteomes:UP000030361};
RN [1] {ECO:0000313|EMBL:AQW21129.1, ECO:0000313|Proteomes:UP000030361}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCTCC M 2011381 {ECO:0000313|EMBL:AQW21129.1,
RC ECO:0000313|Proteomes:UP000030361};
RX PubMed=26021929;
RA Wang Y., Wang Y., Lang C., Wei D., Xu P., Xie J.;
RT "Genome Sequence of Lactobacillus curieae CCTCC M 2011381T, a Novel
RT Producer of Gamma-aminobutyric Acid.";
RL Genome Announc. 3:0-0(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the
CC sodium:galactoside symporter (TC 2.A.2) family.
CC {ECO:0000256|ARBA:ARBA00007724}.
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DR EMBL; CP018906; AQW21129.1; -; Genomic_DNA.
DR RefSeq; WP_035166502.1; NZ_CP018906.1.
DR AlphaFoldDB; A0A1S6QHR1; -.
DR KEGG; lcu:PL11_003915; -.
DR eggNOG; COG2190; Bacteria.
DR eggNOG; COG2211; Bacteria.
DR Proteomes; UP000030361; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR CDD; cd17332; MFS_MelB_like; 1.
DR CDD; cd00210; PTS_IIA_glc; 1.
DR Gene3D; 2.70.70.10; Glucose Permease (Domain IIA); 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR011055; Dup_hybrid_motif.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR001927; Na/Gal_symport.
DR InterPro; IPR018043; Na/Gal_symport_CS.
DR InterPro; IPR001127; PTS_EIIA_1_perm.
DR NCBIfam; TIGR00792; gph; 1.
DR NCBIfam; TIGR00830; PTBA; 1.
DR PANTHER; PTHR45008; PTS SYSTEM GLUCOSE-SPECIFIC EIIA COMPONENT; 1.
DR PANTHER; PTHR45008:SF1; PTS SYSTEM GLUCOSE-SPECIFIC EIIA COMPONENT; 1.
DR Pfam; PF13347; MFS_2; 1.
DR Pfam; PF00358; PTS_EIIA_1; 1.
DR SUPFAM; SSF51261; Duplicated hybrid motif; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS00872; NA_GALACTOSIDE_SYMP; 1.
DR PROSITE; PS51093; PTS_EIIA_TYPE_1; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030361};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597,
KW ECO:0000313|EMBL:AQW21129.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 505..609
FT /note="PTS EIIA type-1"
FT /evidence="ECO:0000259|PROSITE:PS51093"
SQ SEQUENCE 636 AA; 69820 MW; 7C585D592AEDEEA9 CRC64;
MQQKTHKLAS RLSYTFGAFG HDMFYATLST YFVMFITSHL FDKSNGGTGA KMITYITIIM
TSLRIVELVI DPFIGNTIDN TNTRWGHFKP WIVFGGTLGS IILAALFTDL GGLNVSNPWL
YLILFAILYI TMDIFYSFKD IGFWSMIPAL SFDSNEREKI ATFARVGSNI GQNIVGVIVM
PLVLFFSVNA NHGQGDKRGW FAFAAIVALI AWISAMVVAA GTKEIDSDLR KNKEKTTFRG
VLGVLVHNDQ LMWLALTYGI YTTGMAITNS LELYYFTYIL GKPAEFSFLA SLNAVIGVFA
VLAFPPLAQK FKRKNVFFIS ISIMFLALLL FAFSGKSLFM VLFSAVLFYI PQPLVFLVVL
MILTDSVEYG QLKLGHRDES LTLSVRPLLD KLGGAVSNGV VVLTAIIAGM TSGASASDIT
PSGQLAFKFM MFGIPAVMFL IASILFSKKI KLDEKAHAEI VDELEKTWGQ HLGTDDSADT
ESEAQVIDYK APIDGELIDL ANVNDERFAS GEMGKGFAIK PTDGKVYAPF SGTVEVVFPT
RHAVGLKSDN GVVTLIHVGI DTVTMRGTGF ISYVKQGQRV EQGDMLLEFW APAIEKAGLD
DTVLLVISNS DEVHNIEFKQ ASGKVTHGDD VLNITK
//
