ID   A0A1S8B888_9PEZI        Unreviewed;       328 AA.
AC   A0A1S8B888;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Hydroxymethylglutaryl-CoA synthase {ECO:0000313|EMBL:OMP83792.1};
GN   ORFNames=BK809_0005173 {ECO:0000313|EMBL:OMP83792.1};
OS   Diplodia seriata.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetes incertae sedis; Botryosphaeriales; Botryosphaeriaceae;
OC   Diplodia.
OX   NCBI_TaxID=420778 {ECO:0000313|EMBL:OMP83792.1, ECO:0000313|Proteomes:UP000190776};
RN   [1] {ECO:0000313|EMBL:OMP83792.1, ECO:0000313|Proteomes:UP000190776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F98.1 {ECO:0000313|EMBL:OMP83792.1,
RC   ECO:0000313|Proteomes:UP000190776};
RA   Robert-Siegwald G., Vallet J., Abou-Mansour E., Xu J., Rey P., Bertsch C.,
RA   Rego C., Larignon P., Fontaine F., Lebrun M.-H.;
RT   "Draft genome sequence of Diplodia seriata F98.1, a fungal species involved
RT   in grapevine trunk diseases.";
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OMP83792.1}.
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DR   EMBL; MSZU01000111; OMP83792.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1S8B888; -.
DR   STRING; 420778.A0A1S8B888; -.
DR   OrthoDB; 1060at2759; -.
DR   Proteomes; UP000190776; Unassembled WGS sequence.
DR   GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR   GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IEA:InterPro.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR013746; HMG_CoA_synt_C_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43323; 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE; 1.
DR   PANTHER; PTHR43323:SF2; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR   Pfam; PF08540; HMG_CoA_synt_C; 2.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000190776}.
FT   DOMAIN          9..65
FT                   /note="Hydroxymethylglutaryl-coenzyme A synthase C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08540"
FT   DOMAIN          113..328
FT                   /note="Hydroxymethylglutaryl-coenzyme A synthase C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08540"
FT   REGION          65..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..105
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   328 AA;  35100 MW;  EFB082E90645378B CRC64;
     MLVGPDAPLV LDQGTRASFM KHTYDFYKAD FSAEYPIIDG KHSIDCYLEA LDACYRTYHA
     KKKASEIPSR HGAVQNGGAS PSTTTNGGGG APTTTTNGTS SNGTTSPPVP PLPLDTFDYM
     VFHAPTCKLV AKSYARLLHQ DYLSHPTHPA FAGVIDDDDN NNTTAASPSP SANDATWTRT
     REAAFVQLSA PRFASRVAPG TVVATNCGNM YTASVYGGLA GLLGTVASAD LLGKRVGLFS
     YGSGLASSLF SVTVRGDVGP MAEALRITER LAERVTASVE EYDLACAMRE ESYQKPSRDP
     EGDVDSLLPG TYYLAHVDEK FQRTYEVR
//