ID A0A1S8BDR3_9PEZI Unreviewed; 749 AA.
AC A0A1S8BDR3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN ORFNames=BK809_0004285 {ECO:0000313|EMBL:OMP85614.1};
OS Diplodia seriata.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetes incertae sedis; Botryosphaeriales; Botryosphaeriaceae;
OC Diplodia.
OX NCBI_TaxID=420778 {ECO:0000313|EMBL:OMP85614.1, ECO:0000313|Proteomes:UP000190776};
RN [1] {ECO:0000313|EMBL:OMP85614.1, ECO:0000313|Proteomes:UP000190776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F98.1 {ECO:0000313|EMBL:OMP85614.1,
RC ECO:0000313|Proteomes:UP000190776};
RA Robert-Siegwald G., Vallet J., Abou-Mansour E., Xu J., Rey P., Bertsch C.,
RA Rego C., Larignon P., Fontaine F., Lebrun M.-H.;
RT "Draft genome sequence of Diplodia seriata F98.1, a fungal species involved
RT in grapevine trunk diseases.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OMP85614.1}.
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DR EMBL; MSZU01000084; OMP85614.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1S8BDR3; -.
DR STRING; 420778.A0A1S8BDR3; -.
DR OrthoDB; 2712461at2759; -.
DR Proteomes; UP000190776; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR Gene3D; 6.20.120.20; -; 1.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU362003};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022955};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022955};
KW Reference proteome {ECO:0000313|Proteomes:UP000190776};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid biosynthesis {ECO:0000256|ARBA:ARBA00022955}.
FT DOMAIN 104..357
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 410..740
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 749 AA; 85779 MW; CF3F0443EDC18390 CRC64;
MARTTQIGRE HEADAKQRGA PAANGPANGT VSSPVDPSEK TDYTRWRLLD QNGRQTWHYL
ESDEEVARWP QTTADKYFLG LDTGLPELPP AKTPVQAVNN GLSFFSQLQL PSGQWACEYG
GPMFLLPGLV ITWYVTNTPI PDAYKTEIKN YLFSRQHPED DGWGLHIEGQ SSVFGTACNY
TVLRLLGADA EDPRVVRARA CLHRMGGAVN GPHWAKFWLS VLGVTSWDIV NPVPPELWLL
PDWVPIAPWR WWIHMRMVYL PMGYIWSKKW SYQPDKLVLA LRQELFTQPW ESIDWASHRN
SISVHDNYHP KSWVLNTINW GLVNIYNPYL RANALAKRAE DWVWRLVEYE DHNTGYNNLA
PVNAPMNLLC CYIQEGPDSY SVRKHRENLL IYFWVKNEGM LANGTDGVQI WDTSFLIQAA
YEAGVCEDPR WRPVLTKALS FLDKQQIRED IHEADKCYRH KRKGAWAFST KDQGYPVSDC
TAEGLKAVLQ LQSIPDYPQM VSEERLKDSV DLLLTMQNPS GGCSSYEPTR GSELMEYLNA
AEVFDRIMVE YDYPECTTAV VTALCAARAR WPDYRAAEID AFVDRAVTYI RRAQRADGSW
YGSWGICFTY AAMFALESLR CVGETHATSE RVRRACAFFV ERQMPDGGWG ESYRSSEEMR
WVNHEQSQVV QTAWVAIALM EAEFPDKDVI TRAVRLIMQR QQANGEWLQE AIEGVFNNSC
MISYPNYKFT FTMKALGMYA KKYGDKPLL
//
