ID A0A1S8D416_9PROT Unreviewed; 568 AA.
AC A0A1S8D416;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=L-lactate permease {ECO:0000256|ARBA:ARBA00039210, ECO:0000256|RuleBase:RU365092};
GN ORFNames=APZ41_015180 {ECO:0000313|EMBL:ONH82338.1};
OS Roseomonas mucosa.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae; Roseomonas.
OX NCBI_TaxID=207340 {ECO:0000313|EMBL:ONH82338.1, ECO:0000313|Proteomes:UP000054844};
RN [1] {ECO:0000313|EMBL:ONH82338.1, ECO:0000313|Proteomes:UP000054844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SAVE376 {ECO:0000313|EMBL:ONH82338.1,
RC ECO:0000313|Proteomes:UP000054844};
RA Choudhury M.A., Sidjabat H.E., Wailan A.M., Zhang L., Marsh N.M.,
RA Rickard C.M., Davies M., Mcmillan D.J.;
RT "Draft genome sequence of Roseomonas mucosa strain AU37, isolated from a
RT peripheral intravenous catheter.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU365092}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU365092}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the lactate permease family.
CC {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ONH82338.1}.
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DR EMBL; LLWF02000059; ONH82338.1; -; Genomic_DNA.
DR RefSeq; WP_058389357.1; NZ_LLWF02000059.1.
DR AlphaFoldDB; A0A1S8D416; -.
DR STRING; 207340.APZ41_015180; -.
DR OrthoDB; 9761056at2; -.
DR Proteomes; UP000054844; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR003804; Lactate_perm.
DR NCBIfam; TIGR00795; lctP; 1.
DR PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR PANTHER; PTHR30003:SF10; L-LACTATE PERMEASE; 1.
DR Pfam; PF02652; Lactate_perm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519,
KW ECO:0000256|RuleBase:RU365092};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW Reference proteome {ECO:0000313|Proteomes:UP000054844};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365092};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365092};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 40..58
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 70..91
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 118..147
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 154..179
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 199..217
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 224..246
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 252..269
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 316..335
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 385..404
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 424..441
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 448..473
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 545..563
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
SQ SEQUENCE 568 AA; 60211 MW; EC0748F9534BD3A1 CRC64;
MSAWPQNYDP LGNIWLSSLI AFVPIAFFFL ALTVLRLKGY VASTITVVLA LAVAVLFYGM
PAGQALASGA YGFVYGLWPI AWIIIGAVFL YKISVRTGQF EIVRASILSV TEDQRLQLLI
VGFSFGAFLE GAAGFGAPVA ITAALLVGLG FRPLYAAGLC LIVNTAPVAF GAMGIPVIVA
GQVTGLDPFV IGQMAGRQLP FMTLIVLFWV MAIMDGWRGV RETWPAVVVA GGSFAIVQFL
TSNFIGPELP DITSSLASLL CLTLFLRVWR PARIFRFETA EAEASGMARA QPAGAQVATV
GGMAPAAARR HTPGEIILAW SPFLILTAMV TLWSIKPFKS LFAVGGALSG WVIAIPVPSL
HRLVEKMPPI TAGPVPYDAI YRFDWFSATG TAIFLAALLS ALLLRQRPLE TVRTFGETLA
ELRTPIYSIG MVLAFAFIAN YSGLSATLAL ALAHTGAAFP FFSPFLGWVG VFLTGSDTSS
NALFGALQAT TAQQIGVSDI LMVAANTTGG VTGKMISPQS IAIACAAVGL VGRESDLFRF
TVRHSLAFAC MAGLITLAQA YWLTGMIP
//
