ID A0A1S8KXJ7_9CLOT Unreviewed; 423 AA.
AC A0A1S8KXJ7;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN Name=walK_2 {ECO:0000313|EMBL:OOL84427.1};
GN Synonyms=sasA_19 {ECO:0000313|EMBL:URZ13830.1};
GN ORFNames=CROST_046080 {ECO:0000313|EMBL:URZ13830.1}, CROST_44390
GN {ECO:0000313|EMBL:OOL84427.1};
OS Clostridium felsineum.
OG Plasmid p330 {ECO:0000313|EMBL:URZ13830.1,
OG ECO:0000313|Proteomes:UP000190951}.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=36839 {ECO:0000313|EMBL:OOL84427.1};
RN [1] {ECO:0000313|EMBL:OOL84427.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7320 {ECO:0000313|EMBL:OOL84427.1};
RA Poehlein A., Montoya Solano J.D., Flitsch S., Krabben P., Duerre P.,
RA Daniel R.;
RT "Microbial solvent formation.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:URZ13830.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 7320 {ECO:0000313|EMBL:URZ13830.1};
RC PLASMID=p330 {ECO:0000313|EMBL:URZ13830.1};
RA Poehlein A., Schoch T., Duerre P., Daniel R.;
RT "Genome sequence of C. roseum typestrain.";
RL Submitted (APR-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; LZYV01000106; OOL84427.1; -; Genomic_DNA.
DR EMBL; CP096984; URZ13830.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1S8KXJ7; -.
DR STRING; 84029.CROST_44390; -.
DR KEGG; crw:CROST_046080; -.
DR Proteomes; UP000190951; Plasmid p330.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR032834; NatK_C.
DR PANTHER; PTHR45528; SENSOR HISTIDINE KINASE CPXA; 1.
DR PANTHER; PTHR45528:SF9; SENSOR HISTIDINE KINASE YRKQ; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF14501; HATPase_c_5; 1.
DR Pfam; PF00512; HisKA; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OOL84427.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Plasmid {ECO:0000313|EMBL:URZ13830.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OOL84427.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 133..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 158..210
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 225..423
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 423 AA; 49521 MW; 8B48AF38F79D8118 CRC64;
MIISIIFSLV VALSIFVLLE NIGDNILDNY FDKNYFVENQ KKKTLTDFKE YISENHIKMG
DTKKISQWAN KKKYVNLYIY KDNKLIYDHN MDDVDEYTPS QSPVVVLDKE LYNIKFSDEV
GKVYLECFFQ YKYYSITSLI NVTVSFLCFV VIMVFFIRRK TRYIKKLERE LKILEGGNLD
YEITIKGNDE LFSLAQGINE MRKSFVEKLE SEEKARLANT ELITAMSHDL RTPLTALVGY
LDIIEYKKYK TEENLKQYIH NSREKAYQIK CLSDKLFEYF IVFNTADDNI ELESFNGNEL
LDQLLSEQIF ILEDAGFNFK FQACNEPFKL KVNLISIRRV FDNIFSNISK YADKSEYIKV
QYYIEASKLF ICIENKINSN LKDVTSTGIG LKTCKKIIKQ HKGKVISKSG ENIFLVKISL
PIT
//
