ID   A0A1S8TYM7_9CLOT        Unreviewed;       226 AA.
AC   A0A1S8TYM7;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=precorrin-2 dehydrogenase {ECO:0000256|ARBA:ARBA00012400};
DE            EC=1.3.1.76 {ECO:0000256|ARBA:ARBA00012400};
GN   Name=sirC {ECO:0000313|EMBL:OOM82515.1};
GN   ORFNames=CLPUN_01170 {ECO:0000313|EMBL:OOM82515.1};
OS   Clostridium puniceum.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=29367 {ECO:0000313|EMBL:OOM82515.1, ECO:0000313|Proteomes:UP000190890};
RN   [1] {ECO:0000313|EMBL:OOM82515.1, ECO:0000313|Proteomes:UP000190890}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2619 {ECO:0000313|EMBL:OOM82515.1,
RC   ECO:0000313|Proteomes:UP000190890};
RA   Poehlein A., Montoya Solano J.D., Flitsch S., Krabben P., Duerre P.,
RA   Daniel R.;
RT   "Microbial solvent formation.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC       biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00005010}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OOM82515.1}.
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DR   EMBL; LZZM01000010; OOM82515.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1S8TYM7; -.
DR   STRING; 29367.CLPUN_01170; -.
DR   OrthoDB; 1715866at2; -.
DR   UniPathway; UPA00262; UER00222.
DR   Proteomes; UP000190890; Unassembled WGS sequence.
DR   GO; GO:0004325; F:ferrochelatase activity; IEA:InterPro.
DR   GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR028161; Met8-like.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR35330; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR   PANTHER; PTHR35330:SF1; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR   Pfam; PF13241; NAD_binding_7; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:OOM82515.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190890}.
SQ   SEQUENCE   226 AA;  26008 MW;  6F4952A56E7EB7B4 CRC64;
     MCEDNRKDIS SEKIIYSYIS LFSSKLRVGI IGGGKAGTIK AKYFVNNKCY VEVLSKTFSD
     EIVEISEDAR ENLKLVNEEF SYEFLKDKHL IIIAFDDDIL KDKIIRYCDE NFKIYIDSSN
     FKAGIGVIPI QRNTKNVSFA LNTKIGNPKG AVLVSNKVKM LLEEYDDFLE FMGKIRNRAK
     VFPQYKNEIL KVIGNDDFKK SFDEGKSESV LRSNFPKEII DYLLEL
//