ID A0A1S8W2M2_9FUNG Unreviewed; 5579 AA.
AC A0A1S8W2M2;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=BSLG_02404 {ECO:0000313|EMBL:OON08283.1};
OS Batrachochytrium salamandrivorans.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Rhizophydiales;
OC Rhizophydiales incertae sedis; Batrachochytrium.
OX NCBI_TaxID=1357716 {ECO:0000313|EMBL:OON08283.1, ECO:0000313|Proteomes:UP000189906};
RN [1] {ECO:0000313|EMBL:OON08283.1, ECO:0000313|Proteomes:UP000189906}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BS {ECO:0000313|EMBL:OON08283.1,
RC ECO:0000313|Proteomes:UP000189906};
RA Lavstsen T., Jespersen J.S.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OON08283.1}.
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DR EMBL; LYON01000272; OON08283.1; -; Genomic_DNA.
DR STRING; 1357716.A0A1S8W2M2; -.
DR VEuPathDB; FungiDB:BSLG_02404; -.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000189906; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR CDD; cd01460; vWA_midasin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 8.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000189906}.
FT DOMAIN 5370..5570
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 857..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4627..5269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..882
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4647..4661
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4692..4736
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4737..4751
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4782..4822
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4837..4860
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4861..4917
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4934..4964
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4965..4988
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4992..5022
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5028..5071
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5135..5150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5182..5199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5200..5230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5231..5245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5252..5266
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5579 AA; 623267 MW; 449493DA0879786E CRC64;
MPLENTQDGA AADIEEPGFL LDLAPSLTVL LSHPTHSSAL LDYELALLSS SLEQVDTTMP
HIQLQSVLQT LSHLLLRPSL TADICHLFRP IIIDLVARWL LMHPTTYESA LGKSLSINTT
AMLMATASVD VTTNAISGVS SPKHARYGKT INSESSLLEF SPSVLFVEHL AVAFSRLLPI
APQIKAHAIA AFQNSPSLFS SVAFLVKNPS QDATDRLCRI IKSVYRLLEF SRDVFSSIWN
PEPIYALLTY PDAAVRMYAA YSLSILIGMS DAERNTLLEH YTDKNNIDPK LALLPLVEQL
QTESMHARMF ESTSVTLTPG SNAQPRIMMD ASSLSCLTVD MCGVLLPHNQ LTTARFSSSV
RLLPLDTSMI SSGAIQDVSE KMTKLVHIKS TVDNLHQIGI AISLGLPVLL EGPPGVGKTA
LVEEASRILG SSDLLKIHLG DQTDSKLLLG TYMTTSTPGA FKWQPGVLVT AVSEGRWILI
EDIDLAPVDV VAVLVPLLET RWLYIPSRGE RIQAKDSFRI FATRRVAATS NGNSHSEKSR
RRNASQKHLG ESLWTTVFIS ELNNSEIHTI INSRFPVLRG CVGEIMRSYD TLNAQFREMH
AVGRQLSSRD LIKWCYRVSN LYQKKLESSH SQIGSISVEN QREDLFREAF DCFMAMIPKA
HLRQQIALCL GETLQIPQNR IEFYFENFIP NVTLDIPAGK LLCGRVVLPI FDAKIASARH
PPFAPTAPSL RLIERLAVAV SLCEPILLVG ETGTGKTTVV QHLASHVGSK LTVINMSQQS
DSTDLLGGFK PVDALLLAAK VREEFESLFS RTFSVKNNSA FLASVQKAFI RRNWHQLSIG
FERAVKMAKE VMSKIHAGTV AQKDKNQPED ESAPKKKRKH LDPSLAVEWD QFEISVNQLS
AQLEQIKNNF LFSFVEGSLI QALRNGHWIL LDEVNLASAE TLECLSGLLQ SSDGSIMLLE
RGDTVPIRRH PNFRLFACMN PANDAGKRDL PPGLRSRFTE FWVESPDACQ ADLLLIIRSY
IFPHLPAGPA GDRICLDVAE FYSEAKSLAV QGILFDGADQ RVHISMRTLT RALSYAMFIA
PMYGIKRSLY EATYMTFMTG LGIKSWQQMM TMLRKSILNG VRNPDAFVKQ IPKHPGVQDD
MADLDEDILR DSPYTLIDCF WIEKGPLDIP TDLESAFVLT PSVQANLVNL SRAVLSRKYP
VLIQGPTSAG KTSMVEYLAK RTGHRFLRIN NHEHTDIQEY LGSYISNDQG ALAFQDGVLV
EALRKGYWIV LDELNLAPSD VLEALNRLLD DNRELFLPET QEVIKPHPHF MLFATQNPAG
QYGGRKQLSR AFRNRFVELH FSDIPEGELE MIMEKRCRIA PSYAKRLVSV YKSLQKLRGT
SRIFDGRQSF ITLRDLFRWA LRGAVGYQRL AEDGYMQLAE RVRKLDDRAA IKKILEKEFK
VVIDEEAMYD TMFEKIWSSL KMLAETSPEI SCLVDGIVWT QAMRRLFVLV HECMQHYEPV
LLVGETGCGK TTVCQILAAL AQRHLHIVNA HQNSETADFL GSQRPTRGRE QAEIELRKQV
RILIDKAAPQ TSGSFDLEME KVGSIMDKVE EISTSLESLG LDKSVKHSLQ TEISTCLKLC
QKSRALFAWT DGPLVQAMKL GHFFLLDEIS LADDSVIERL NSVLEPQRLL VLAENGAKEV
EEIIAADEFR LFATMNPGGD YGKKELSPAL RNRFTEIWVP SIVSRSDLLL ILEKKLCVLQ
IPSDARILWG GRILDFLYWL AEQLHKPIDA IISLRDILAW ASFLCATGLR LGLADAFFHG
GCMVLIDGMS INPLLGTLGT SCASLSKTSR YILRSLSKGV GITDIVVHET LLESEGVEFD
TSASPLVIRQ LEFGNDLFCI PVGNAMIKSA SFAMQAPTTL SNCMRVLRAL QLNKPILLEG
SPGVGKTSLI ASLAAMSRHR LVRINLSEQT DLMDLFGSDL PVENGHGGEF AWRDGPFLKA
MQEGDWVLLD ELNLASQQVL EGLNSCLDHR ATIYIPELDR NIACHPSFRV FAAQNPQNEG
GGRKGLPKSF SNRFSQVYVS PLDMHSLRYI CSALYPHLDT ELTEKMIVFN ERIREEIMVK
CSFGWRGAPW EFNLRDVLRW IDMWQTSLSR FDDDAKKLDA GPGEFLEMIY TQRMRTRNDR
NRVREIFVDI FGYLPDRCVN RPTLRITPNL VKIGNALLPR VALRGTHKYG APTDNLQILP
SSLPFLESLV QCIQTCSLPL LVGPSAVGKS SLVRLLSSIA GQRLHEITLN PGVDALELLG
GFEQVDLVRR SQGIVDDIEE LMNMVLATGI LKPNIVSSST LAQIQADWSI FCLNRVTVPM
EESMSALRRL LGDLKAVSSS LFPSLDAFED IQSSIEAYSR LADSGIRGRF EWMDSALVRA
LKHGDWILID NVNLCSESVL DRLNSLVETN GCLIISERGL VDGDIQIITP HPNFRLFMAM
DPTYGEISRA MRNRSVEIYI DDFEKSVDSN VVSVTKLTSA AGFLGDALAT VLARTSSDAI
GFDSFDQENT DSRTPVLDAR LIVEHLQRGD TLETALMSIL DADTASSVLK SMATYGGVFP
TCWPLFVSGK LTIQCSELAS VASSASAIVM YTSSLASELK FVSPVARMPL LSELPSIHDL
VVAALDVFIQ DVSVSDLHLR KSWLSFWAEN LGSDADPMFI EALKLALFLM ETDHVVTAIG
HAGVAARAEF ARVGISGSDA DKFPVDLQLV DLAGIQPAKS SSTSDTVLFN IRRFCSDQFI
ENSVYDASSS ILVRDLNISQ LSYSLFIGKV RASQLPHACV RSLYPLLCST QTVCKSALFS
CMNSSDLNLT PIVKLMDRRR ELWESAQTVV VDIAKLVLCI RRISKLLPAC IALCDANSID
ITSLHSSIED AWESFSVEKI KALGVLWKLG GITTLRTTVL STIADQFESV NAVLDTSSQG
PSAWIFRRTI TSMGLDIKRA IMEGVSTLHY LNEEEEPSNN LVTMLQEVPA KLTESITKLD
TPQPISLLAM SGIDSQLSAV TLWPFHDTWA LASELTLIEQ IYAYLHDEHP DNQLLVRSIR
SFISSAITST SLPPLHFEPL QRLVWVLDSG SNQHTPHVVS DQSQHQFVYT IAQEALHQWN
KSFWANGFTF WRSHSMTDRE SFMMNGQILQ LLDLESEIAS GLSMSSGKQT LQSMHVPLYN
GLSGHTLAML ESISKVPVYS SGSKVIQMKM LLQQTASPDF EVAQRNKFDL SVLIACIIQF
LRAHSSLYPP GTLASIQTAL DHAISPHKPS MESADIERLK EMLLQVKSAR MQTIIKLYLS
PMIDSIAVCS QTLPCSETQL NIEFANAWVL YALAFLEAYI PDLPVDPVAM RTAKISLSTR
YSDRLKADIL VNADKEFLQT ANPPSPKLKT KLADLEDEAA KMFKWRSKLP IRPSRSQMVD
IVNELQQVKQ SILHLPTIKL LLVELVSPSG VSLDILHQEE SLQDVVQSVI DRIEAKYPHY
RDLLLPACTA LYQLKYGIRL MRHAGSILHL RDASTSVAPL VRFVQDFQLE NLDVALENAS
SIRGNSRQLM QTKLKIQLAT IEQLAAFLQT GTHIDVDVII RMHALFDAVV DLWGEAEVQR
QRMEEEKESL FIMKQASVVT DEEREEAEFR ERFPDFFETF ADIAPVDPLN DSDPLKNAPT
VPKQPAIIPT FDPSQAWRIV LSYKAAVDTL SSTSPETFSK QWGGAFLSSL DAAMTVCQLD
GVSVPPTMDV IGRLGFVYAS AKHVSDFSTT TVTSSDLYDF YNDSNVFEAQ QIQPLLVKFD
TRINALLVQW PDHDVLVHLS AICRRVASFP VASPLMKLLT GIELLLTKSQ DWEAYASKEV
SLRSCLDDFV LFIVKWRRLE LNTWRQLLKL EERRCAAKVG SLWFHLWRTT MGILRNPKPE
SHELDALKDP LVNDLFTTFD NLCLSSPVGQ FEERLQILRS FHKHLLLLEK HCPCDMFTGL
KTIINLLWNV TEYYFQFLPS VQLFISTSRK PILTELKKYV KIATWKDVNV FALKESAKRT
HYNLNKFVKK YMLVLEKPVK DVIASFQEAP PSMSTLPART TIDPDVMWDM ALTSAADSCQ
TALCVPLALI IDESNLGTKY RVSNTERLLA KMKSLTRSVI SENIFAGAAS GIEEFSATIL
ERVKAFRDVN VAAQSDVKIV KGQKMMRKKA LVDLLRYLAV LGLSQRCRQR FAYHQDPFVM
NSYAPLDMSL LVNSIAELGS STWMLPELRV LADRTHEYHF RNLARIAVVR SATLSIPPDL
TLLETERGIS SIEHLLNFSL EQRDLISSFS KHMCQISSFV KQMHSIVENG PQIRFEPSRV
YHNQLVAIKR ATDNAMIVVS QSIDVASLAN EHGHPISLRF RERLTCVANQ LKEKKTRVDN
SYQLYVSTHL PPLVAIKDTD TQDVGDYQYM VDALNSVYTD LSSIQSDFPE HDLFIRDAVS
LVKSGLVSLD SPVAAIESTE PLLQDTNVIS NTLMVKADVV VERLLVAFQH LRTPSPTLDI
LSTTKLGSTE EIESEKDEFG LGTNHLIDMH NLTKAVFEYQ SGASLLSSVA DLLAIIDDAI
SNGDAKVASQ IHALLTQIAP LFGQYYALAQ YRLLQHFSFS KAISKLTYVL ANLFASLLKE
GFCLPKSSEG EDDENAGAME DNVEGTGMGE GDGKKDVSDE IENEDQAEGA QIENAKQPPP
DLEKNIDDED NGIEMTNDFD GVLEDVDGDD DDEMDDPDDK DDDQEPDEEM GDLDKDLADV
VDEKLWGDDD KDDNNENAED DEKTERDAPV DGGAGESEIV AEENGSDEKP KKEKDPKEAT
PSKQPDDDTP DDTDKQDDVP KENDDSPDVE DNDPERINED APDKFEDSHG VDVKAADDLD
KDGESDDDDV ADDGSDIPDK MDIDEDDAND SDANGETNNA QEDEMDIVDE DVVQEDTPQE
IDQNQSHDQS LDAEDESDDK EPDNEPENEP ENAEEDEEGA DTMNITGDEP EKDPGSEKKP
EEAKGSAAEM NPHDQIQPSN QPFGVQSQQA SEAIQGEDSE AQNEQQADGD DGEAHATEDS
QGGKSNSKPE RRDNKQSQPD HGPKDANPRR SVGDAMKQWL SRLKHIAESS EEQDAVDNDQ
ENTVQQNVTD DNDFEFVEND EHAGDTQALG AATDDQLEKM DRQALADDEK EGECQNEEAS
MDVDEPFENI GPDEKMQADN KDKPLPNSSS AQSISEKQQP KEKVSPDEPA STHDDASDGD
KEDTRTPEKD GKSNSNLLGP GQSRNTDEDQ QDDKEDNLEE HDEATEEIDY ASLRRELESR
MMTFRQNGVN DQQKVQELWR SYVNLTRDLA FSLCEQLRLI LEPTLATKLK GDYRTGKRLN
MRKVISYIAS QFKKDKIWLR RTKPSKRTYQ VMVAVDDSRS MSESHSIQLA FESLAMISKA
LTQLEVGDIG IVRFGENVQL VHPFEKPFTD DAGADLIRSF TFEQDRTHVK LMMESAMSIL
EHARFSNSQS SADLWQLQLV ISDGICEDHE YIRSLVRKAT EERIMIVFII LDNRTEKDSI
LNMTNVSYEM DFATQRPILK MDRYMDTFPF DYYVVVRDIE RLPEILAETL RQFFMFVSS
//
