ID A0A1S9AK09_9BURK Unreviewed; 1066 AA.
AC A0A1S9AK09;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Peptidase S8 and S53 subtilisin kexin sedolisin {ECO:0000313|EMBL:OON63789.1};
GN ORFNames=B0920_10685 {ECO:0000313|EMBL:OON63789.1};
OS Massilia sp. KIM.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Telluria group; Massilia.
OX NCBI_TaxID=1955422 {ECO:0000313|EMBL:OON63789.1, ECO:0000313|Proteomes:UP000190838};
RN [1] {ECO:0000313|EMBL:OON63789.1, ECO:0000313|Proteomes:UP000190838}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM {ECO:0000313|EMBL:OON63789.1,
RC ECO:0000313|Proteomes:UP000190838};
RA Vikram S., Kabwe M.H., Bezuidt O., Govender N., Makhalanyane T.P.;
RT "Genome sequence of Massilia sp. KIM isolated from grassland biome soil in
RT South Africa.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OON63789.1}.
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DR EMBL; MVAD01000001; OON63789.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1S9AK09; -.
DR STRING; 1955422.B0920_10685; -.
DR OrthoDB; 614750at2; -.
DR Proteomes; UP000190838; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02120; PA_subtilisin_like; 1.
DR CDD; cd04852; Peptidases_S8_3; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 2.60.40.2310; -; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034197; Peptidases_S8_3.
DR InterPro; IPR010259; S8pro/Inhibitor_I9.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR InterPro; IPR045051; SBT.
DR InterPro; IPR041469; Subtilisin-like_FN3.
DR PANTHER; PTHR10795; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN; 1.
DR PANTHER; PTHR10795:SF468; SUBTILISIN-LIKE PROTEASE SBT3.18; 1.
DR Pfam; PF17766; fn3_6; 1.
DR Pfam; PF05922; Inhibitor_I9; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000190838};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1066
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012865540"
FT DOMAIN 29..130
FT /note="Inhibitor I9"
FT /evidence="ECO:0000259|Pfam:PF05922"
FT DOMAIN 158..656
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 468..533
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 728..821
FT /note="Subtilisin-like protease fibronectin type-III"
FT /evidence="ECO:0000259|Pfam:PF17766"
FT REGION 252..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 167
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 261
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 623
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1066 AA; 109080 MW; FC1078FFC19D5478 CRC64;
MKLRPISLAV LAVLSSAALS ASADGVRRSY IVQLADKPVA TYTGEVSGLP ATKPAPGQHL
DVSAADVQAY IQYLEKKQNS VLASVNAAQL THKYKLVFNG FAARLTESEV KALKADPAVA
AISADEERTL DTNFTPTFLG LDKPGGLWSK ELNNKSKGED VIIGIVDGGI WPENPAFADR
VDGEGNPTFE ASGTLAYGAP PAKWNGACIE GEGFTAQNCN NKLIGARYFN ETFLSTGREM
HWSDFVSPRD SVDGPTAHGG HGTHTASTAG GNSNVAINLN GIPMGKASGI APRARIAAYK
VCWTYPDPSA TDGTGTRNSC FNSDSVAAID QAVADGVDVI NFSISGSQTS VTDPVELAFF
GASNANVFVA TSAGNAGPAN AVAHLSPWVT TVAASTHNRL NGATATVSNG ATYTGASLNT
SPLPATTAIS ARDAGMKPFA QLNAADQEAL RLCYTDANRI QWPASADAAL DPAKVKDKVV
LCERGTNPRV DKSKAVADAQ GVGMVLIDTG TSLVSEIHSV PTVHLTKTDG EALRSYVQSN
PAATVAISSW SLMTSFIPAP VTAGFSSRGP NRGYASILKP DLIAPGVDII AGHSPVKTQA
ERDAIASGSG TPGAAWASLQ GTSMASPHVA GLGALLKQLH PNWSPAAIKS SLMTTGGATF
NDGLPGAQNG RLPWGQGAGH VQPNLAFDPG LVYDANILDY ARFMCGSGAG AVFAPGTCSQ
IGTIQAHNLN LPSLTAGSVL GKLSMTRTVT NVSGAQATFT PSATLDGFTV SVSPASLTLA
PGAKASYTVN LTRTSAPLDQ YSFGSLEWNS NLGHKVRSPL TARAQALSAP ATLHSEQVTG
NIVYTIGTGY NGKLGALQGG LKPATLNQQT VGQTLAADGG VAECAAGGSS GVKATSFTVP
ANTMVARFSL RDLDTSGYQA GFADDLDLIV YGPSNTQVGY SGNATSNEMV TLVAPAAGTY
RVCVAGYAPR GGSSTYTLAS WVVGAGETGG NLKVSLPGSV FLAGTASAVA SWSGLTPDTR
YLAAIRYLNG SATVGTSLLE VDATNPVPTP GPVGKPPKAG AVTSLR
//
