ID A0A1S9ZTE4_9GAMM Unreviewed; 707 AA.
AC A0A1S9ZTE4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=B0181_11440 {ECO:0000313|EMBL:OOR86799.1};
OS Moraxella caviae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Moraxella.
OX NCBI_TaxID=34060 {ECO:0000313|EMBL:OOR86799.1, ECO:0000313|Proteomes:UP000190435};
RN [1] {ECO:0000313|EMBL:OOR86799.1, ECO:0000313|Proteomes:UP000190435}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG 355 {ECO:0000313|EMBL:OOR86799.1,
RC ECO:0000313|Proteomes:UP000190435};
RA Engstrom-Jakobsson H., Salva-Serra F., Thorell K., Gonzales-Siles L.,
RA Karlsson R., Boulund F., Engstrand L., Moore E.;
RT "Draft genome sequence of Moraxella caviae CCUG 355 type strain.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OOR86799.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MUXU01000095; OOR86799.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1S9ZTE4; -.
DR STRING; 34060.B0181_11440; -.
DR OrthoDB; 6647925at2; -.
DR Proteomes; UP000190435; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029464; HSDR_N.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF13588; HSDR_N_2; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:OOR86799.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000190435};
KW Transferase {ECO:0000313|EMBL:OOR86799.1}.
FT DOMAIN 32..147
FT /note="Type I restriction enzyme R protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13588"
FT DOMAIN 303..579
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 707 AA; 80957 MW; CF9A01540CA39598 CRC64;
MALGIKNKLI FISPENRIEY LFEKRSRNFS NPEEQVQAEV YCRLILQYGY PKERIRNFVS
VTMGSTTKEA DIVVYRDDKC EQPHILVECK KAEVSEAEFV QAVNQAYSYA YALPNNVKFV
WVTSSIKNEY FSVDKSKNTR TTLPDIPPFG VDKLASYKFV KGTKPSAEKG KQQFFDLQIV
DEADLTRRFK QAHNALWAGG QLNPSEAFDE LDKLIFCKIW DERKPRKDGT PYDFQLMLDF
DEQNEDGIKK NNQALLNRIT ALYAEGRTKD PEVFKDNIRL SPERVRTIVG YLQEVSLSKT
DLDSKGRAFE TFMGSFFRGE FGQFFTPRRV VKFIVDVLPI THDSYVLDTS CGSGGFLLHA
LDKVRREADE YYQDGTPEHH RHWHDFAEKK LYGIEINEQI SRTAKMNMII HDDGHTNVIS
ADGLLSDGEL QNQSNNLGFK YNHFDFIITN PPFGSTVKQT EKAYLANYSF GLKDVSWLDI
KNSGVQNRDT QATEVLFIEQ CHNFLKPNGY LAIVIPDGIL TNSSLQYVRD SIEEKFRIIA
VVSLPQTAFK ATGAGVKSSV LFLRKYDASE TKRLSDIKKD IQTAIKNRHQ YEATLKAWDS
EKKAILKNAT GIDFEGDLKA FKKTEQYKMW KNEINSEYSD KITTLKENLL DEYLAQKQAQ
LPDYPIFMAI AEHIGYDATG KDTAINELDV IGTELARFIM GVNHGEF
//
