ID   A0A1T0AUD9_9PAST        Unreviewed;       549 AA.
AC   A0A1T0AUD9;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Bifunctional UDP-sugar hydrolase/5'-nucleotidase {ECO:0000313|EMBL:OOS00206.1};
GN   Name=ushA {ECO:0000313|EMBL:OOS00206.1};
GN   ORFNames=B0188_10835 {ECO:0000313|EMBL:OOS00206.1};
OS   [Haemophilus] felis.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae.
OX   NCBI_TaxID=123822 {ECO:0000313|EMBL:OOS00206.1, ECO:0000313|Proteomes:UP000190023};
RN   [1] {ECO:0000313|EMBL:OOS00206.1, ECO:0000313|Proteomes:UP000190023}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCUG 31170 {ECO:0000313|EMBL:OOS00206.1,
RC   ECO:0000313|Proteomes:UP000190023};
RA   Engstrom-Jakobsson H., Salva-Serra F., Thorell K., Gonzales-Siles L.,
RA   Karlsson R., Boulund F., Engstrand L., Kristiansson E., Moore E.;
RT   "Draft genome sequence of Haemophilus felis CCUG 31170 type strain.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the 5'-nucleotidase family.
CC       {ECO:0000256|ARBA:ARBA00006654, ECO:0000256|RuleBase:RU362119}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OOS00206.1}.
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DR   EMBL; MUYB01000056; OOS00206.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1T0AUD9; -.
DR   STRING; 123822.B0188_10835; -.
DR   OrthoDB; 9803927at2; -.
DR   Proteomes; UP000190023; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0008252; F:nucleotidase activity; IEA:UniProt.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0009166; P:nucleotide catabolic process; IEA:InterPro.
DR   Gene3D; 3.60.21.10; -; 1.
DR   Gene3D; 3.90.780.10; 5'-Nucleotidase, C-terminal domain; 1.
DR   InterPro; IPR008334; 5'-Nucleotdase_C.
DR   InterPro; IPR036907; 5'-Nucleotdase_C_sf.
DR   InterPro; IPR006146; 5'-Nucleotdase_CS.
DR   InterPro; IPR006179; 5_nucleotidase/apyrase.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   PANTHER; PTHR11575; 5'-NUCLEOTIDASE-RELATED; 1.
DR   PANTHER; PTHR11575:SF46; PROTEIN USHA; 1.
DR   Pfam; PF02872; 5_nucleotid_C; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   PRINTS; PR01607; APYRASEFAMLY.
DR   SUPFAM; SSF55816; 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR   PROSITE; PS00786; 5_NUCLEOTIDASE_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|RuleBase:RU362119, ECO:0000313|EMBL:OOS00206.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362119};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190023};
KW   Signal {ECO:0000256|RuleBase:RU362119}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|RuleBase:RU362119"
FT   CHAIN           23..549
FT                   /evidence="ECO:0000256|RuleBase:RU362119"
FT                   /id="PRO_5011822620"
FT   DOMAIN          32..251
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
FT   DOMAIN          364..509
FT                   /note="5'-Nucleotidase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02872"
SQ   SEQUENCE   549 AA;  61159 MW;  2E2A46145060031E CRC64;
     MKTLTKLSAI MLSLGIATQV SAYTQDKTYH ITVLHLNDTH GHFWKNNNGE YGFAAHKTLI
     DNIRKEVESK NGLVVLLHAG DFNAGVPESD MLNAKPDIEG MNMIGYDAAV LGNHEFDFPM
     QLLQMQETWA KFPLLSANVI NKKTNKPLVR PYVVLNKEDV KIAVVGLTTE DTAKLGNPDV
     VDHVIFKNPI ETAKHTLAEI NQTEKPDIRI ALTHMGYYFD AQHGQNAPGD VSLARTLDKG
     AFDLIIGGHT HDTLCIDEKG QFKAKYTPGE ACQPDFQNGT WIVQAGEWGK YVGRADFEFK
     NGETKLVKYE LIPVNLKQKI KLENGKTEYK LYQTEIAEDP AVFTHLKKYQ DEGDRLLGVK
     VGEVKGKFVG DRKIIRFQQT NLGRLIAQSQ MERVKADVGI MNSGGIRADI NEGETTYKDL
     LTVQPFGNMI ATVDLTGQEL LDYLNVVAMK QVDSGAYPQF AGISMIVDRE AQRVSNVKIG
     GKALDLNKTY KVSVPDYCAG GGDGYPVLKK HPSYVNTGFI DAEMLKKYFE ENKVLDASKY
     EPKDDIVFK
//